LYPD5_HUMAN
ID LYPD5_HUMAN Reviewed; 251 AA.
AC Q6UWN5; Q6PEX9; Q96DR2;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Ly6/PLAUR domain-containing protein 5;
DE Flags: Precursor;
GN Name=LYPD5; ORFNames=UNQ1908/PRO4356;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS PRO-90 AND
RP SER-167.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS PRO-90 AND
RP SER-167.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 26-40.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- INTERACTION:
CC Q6UWN5; O15155: BET1; NbExp=3; IntAct=EBI-17200970, EBI-749204;
CC Q6UWN5; Q08426: EHHADH; NbExp=3; IntAct=EBI-17200970, EBI-2339219;
CC Q6UWN5; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-17200970, EBI-711490;
CC Q6UWN5; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-17200970, EBI-10976398;
CC Q6UWN5; Q01628: IFITM3; NbExp=3; IntAct=EBI-17200970, EBI-7932862;
CC Q6UWN5; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-17200970, EBI-10317425;
CC Q6UWN5; Q96GM1: PLPPR2; NbExp=3; IntAct=EBI-17200970, EBI-12955265;
CC Q6UWN5; P30536: TSPO; NbExp=3; IntAct=EBI-17200970, EBI-6623146;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UWN5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UWN5-2; Sequence=VSP_017447;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57816.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY358719; AAQ89081.1; -; mRNA.
DR EMBL; AK055031; BAB70840.1; -; mRNA.
DR EMBL; BC057816; AAH57816.2; ALT_INIT; mRNA.
DR CCDS; CCDS12631.1; -. [Q6UWN5-2]
DR CCDS; CCDS46096.1; -. [Q6UWN5-1]
DR RefSeq; NP_001026919.2; NM_001031749.2. [Q6UWN5-1]
DR RefSeq; NP_001275692.1; NM_001288763.1. [Q6UWN5-2]
DR RefSeq; NP_872379.2; NM_182573.2. [Q6UWN5-2]
DR RefSeq; XP_011525096.1; XM_011526794.2.
DR AlphaFoldDB; Q6UWN5; -.
DR SMR; Q6UWN5; -.
DR BioGRID; 129836; 15.
DR IntAct; Q6UWN5; 11.
DR STRING; 9606.ENSP00000367185; -.
DR GlyGen; Q6UWN5; 2 sites.
DR iPTMnet; Q6UWN5; -.
DR PhosphoSitePlus; Q6UWN5; -.
DR BioMuta; LYPD5; -.
DR DMDM; 90185272; -.
DR MassIVE; Q6UWN5; -.
DR PaxDb; Q6UWN5; -.
DR PeptideAtlas; Q6UWN5; -.
DR PRIDE; Q6UWN5; -.
DR ProteomicsDB; 67504; -. [Q6UWN5-1]
DR ProteomicsDB; 67505; -. [Q6UWN5-2]
DR Antibodypedia; 31133; 50 antibodies from 12 providers.
DR DNASU; 284348; -.
DR Ensembl; ENST00000377950.8; ENSP00000367185.2; ENSG00000159871.15. [Q6UWN5-1]
DR Ensembl; ENST00000414615.6; ENSP00000408433.1; ENSG00000159871.15. [Q6UWN5-2]
DR Ensembl; ENST00000594013.5; ENSP00000471692.1; ENSG00000159871.15. [Q6UWN5-2]
DR Ensembl; ENST00000651184.1; ENSP00000498724.1; ENSG00000159871.15. [Q6UWN5-2]
DR GeneID; 284348; -.
DR KEGG; hsa:284348; -.
DR MANE-Select; ENST00000377950.8; ENSP00000367185.2; NM_001031749.3; NP_001026919.2.
DR UCSC; uc002oxm.5; human. [Q6UWN5-1]
DR CTD; 284348; -.
DR DisGeNET; 284348; -.
DR GeneCards; LYPD5; -.
DR HGNC; HGNC:26397; LYPD5.
DR HPA; ENSG00000159871; Tissue enriched (skin).
DR MIM; 619618; gene.
DR neXtProt; NX_Q6UWN5; -.
DR OpenTargets; ENSG00000159871; -.
DR PharmGKB; PA142671492; -.
DR VEuPathDB; HostDB:ENSG00000159871; -.
DR eggNOG; ENOG502SVAB; Eukaryota.
DR GeneTree; ENSGT00940000153599; -.
DR HOGENOM; CLU_102584_0_0_1; -.
DR InParanoid; Q6UWN5; -.
DR OMA; QKGCWTG; -.
DR OrthoDB; 1102918at2759; -.
DR PhylomeDB; Q6UWN5; -.
DR TreeFam; TF337629; -.
DR PathwayCommons; Q6UWN5; -.
DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR SignaLink; Q6UWN5; -.
DR BioGRID-ORCS; 284348; 14 hits in 1067 CRISPR screens.
DR ChiTaRS; LYPD5; human.
DR GenomeRNAi; 284348; -.
DR Pharos; Q6UWN5; Tdark.
DR PRO; PR:Q6UWN5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6UWN5; protein.
DR Bgee; ENSG00000159871; Expressed in skin of leg and 106 other tissues.
DR ExpressionAtlas; Q6UWN5; baseline and differential.
DR Genevisible; Q6UWN5; HS.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SUPFAM; SSF57302; SSF57302; 2.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Direct protein sequencing;
KW Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Reference proteome;
KW Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 26..225
FT /note="Ly6/PLAUR domain-containing protein 5"
FT /id="PRO_0000226763"
FT PROPEP 226..251
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000226764"
FT DOMAIN 135..214
FT /note="UPAR/Ly6"
FT LIPID 225
FT /note="GPI-anchor amidated alanine"
FT /evidence="ECO:0000255"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..43
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_017447"
FT VARIANT 47
FT /note="P -> A (in dbSNP:rs114779742)"
FT /id="VAR_052704"
FT VARIANT 90
FT /note="A -> P (in dbSNP:rs11547806)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14702039"
FT /id="VAR_059885"
FT VARIANT 167
FT /note="N -> S (in dbSNP:rs349053)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14702039"
FT /id="VAR_059886"
FT CONFLICT 194
FT /note="T -> S (in Ref. 3; AAH57816)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 251 AA; 26936 MW; 16AA033E01B115FC CRC64;
MAMGVPRVIL LCLFGAALCL TGSQALQCYS FEHTYFGPFD LRAMKLPSIS CPHECFEAIL
SLDTGYRAPV TLVRKGCWTG PPAGQTQSNA DALPPDYSVV RGCTTDKCNA HLMTHDALPN
LSQAPDPPTL SGAECYACIG VHQDDCAIGR SRRVQCHQDQ TACFQGNGRM TVGNFSVPVY
IRTCHRPSCT TEGTTSPWTA IDLQGSCCEG YLCNRKSMTQ PFTSASATTP PRALQVLALL
LPVLLLVGLS A
