LYPD5_MOUSE
ID LYPD5_MOUSE Reviewed; 256 AA.
AC Q9D7Z7; Q0VDW0;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Ly6/PLAUR domain-containing protein 5;
DE Flags: Precursor;
GN Name=Lypd5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
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DR EMBL; AK008654; BAB25810.1; -; mRNA.
DR EMBL; BC107186; AAI07187.1; -; mRNA.
DR EMBL; BC107187; AAI07188.1; -; mRNA.
DR EMBL; BC119485; AAI19486.1; -; mRNA.
DR EMBL; BC119486; AAI19487.1; -; mRNA.
DR CCDS; CCDS39830.1; -.
DR RefSeq; NP_084082.1; NM_029806.1.
DR AlphaFoldDB; Q9D7Z7; -.
DR SMR; Q9D7Z7; -.
DR STRING; 10090.ENSMUSP00000032683; -.
DR GlyGen; Q9D7Z7; 2 sites.
DR PhosphoSitePlus; Q9D7Z7; -.
DR PaxDb; Q9D7Z7; -.
DR PRIDE; Q9D7Z7; -.
DR ProteomicsDB; 295739; -.
DR Antibodypedia; 31133; 50 antibodies from 12 providers.
DR Ensembl; ENSMUST00000032683; ENSMUSP00000032683; ENSMUSG00000030484.
DR GeneID; 76942; -.
DR KEGG; mmu:76942; -.
DR UCSC; uc009fpj.1; mouse.
DR CTD; 284348; -.
DR MGI; MGI:1924192; Lypd5.
DR VEuPathDB; HostDB:ENSMUSG00000030484; -.
DR eggNOG; ENOG502SVAB; Eukaryota.
DR GeneTree; ENSGT00940000153599; -.
DR HOGENOM; CLU_102584_0_0_1; -.
DR InParanoid; Q9D7Z7; -.
DR OMA; QKGCWTG; -.
DR OrthoDB; 1102918at2759; -.
DR PhylomeDB; Q9D7Z7; -.
DR TreeFam; TF337629; -.
DR Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR BioGRID-ORCS; 76942; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q9D7Z7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D7Z7; protein.
DR Bgee; ENSMUSG00000030484; Expressed in tail skin and 36 other tissues.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Repeat; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..225
FT /note="Ly6/PLAUR domain-containing protein 5"
FT /id="PRO_0000226765"
FT PROPEP 226..256
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000226766"
FT DOMAIN 133..212
FT /note="UPAR/Ly6"
FT LIPID 225
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 256 AA; 27450 MW; D66B55762C8D767B CRC64;
MGIPRTFLHC FLGSLLCLTG SQALQCYSYE HTYFGPFDLS AVKLPSVSCP EGCSEVVLSL
DTGYRSLVTM VRKGCWTGPT TGPMQTNQDA LPPDYAVVRG CATDYCNSNL KTHDALPNLS
QAPNPQTLSG TECYACLGTH PEDCSPEKSR RVQCHQDQSA CFQGNGRMNI GNFSVPVYIR
TCHRPSCTTM GTTSPWTSID LQGYCCEGHL CNRASVTQIL PGTMSSAPPR APRILTLLTA
APLLAIALGA SVGFPA
