LYPD6_DANRE
ID LYPD6_DANRE Reviewed; 174 AA.
AC Q66IA6;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Ly6/PLAUR domain-containing protein 6;
DE Flags: Precursor;
GN Name=lypd6;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larva;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND INTERACTION WITH
RP FZD8 AND LRP6.
RX PubMed=23987510; DOI=10.1016/j.devcel.2013.07.020;
RA Oezhan G., Sezgin E., Wehner D., Pfister A.S., Kuehl S.J.,
RA Kagermeier-Schenk B., Kuehl M., Schwille P., Weidinger G.;
RT "Lypd6 enhances Wnt/beta-catenin signaling by promoting Lrp6
RT phosphorylation in raft plasma membrane domains.";
RL Dev. Cell 26:331-345(2013).
CC -!- FUNCTION: Acts as an important regulator of embryogenesis through its
CC enhancement of Wnt/beta-catenin signaling. Positively regulates
CC Wnt/beta-catenin signaling by ensuring phosphorylation of lrp6
CC specifically in plasma membrane rafts and its subsequent
CC internalization into signaling-competent vesicles. Essential for the
CC wnt8-mediated patterning of the mesoderm and neuroectoderm during
CC gastrulation (PubMed:23987510). {ECO:0000269|PubMed:23987510}.
CC -!- SUBUNIT: Interacts with fzd8 and lrp6 (PubMed:23987510).
CC {ECO:0000269|PubMed:23987510}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23987510};
CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:23987510}. Membrane raft
CC {ECO:0000269|PubMed:23987510}.
CC -!- DEVELOPMENTAL STAGE: Initially detected in mesendodermal cells at late
CC blastula stages. During gastrulation, expressed in a broad marginal
CC domain and becomes excluded from the ventral animal pole at late
CC gastrula stages. During segmentation, initially exclusively detected in
CC the somitic mesoderm but later also in the otic and optic vesicles.
CC During organogenesis, expression is largely down-regulated in the
CC somites but maintained in the otic vesicles and the retina.
CC {ECO:0000269|PubMed:23987510}.
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DR EMBL; CR394542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC081426; AAH81426.1; -; mRNA.
DR RefSeq; NP_001004670.1; NM_001004670.1.
DR AlphaFoldDB; Q66IA6; -.
DR SMR; Q66IA6; -.
DR STRING; 7955.ENSDARP00000013064; -.
DR PaxDb; Q66IA6; -.
DR Ensembl; ENSDART00000020884; ENSDARP00000013064; ENSDARG00000004307.
DR GeneID; 447932; -.
DR KEGG; dre:447932; -.
DR CTD; 130574; -.
DR ZFIN; ZDB-GENE-040912-117; lypd6.
DR eggNOG; ENOG502RYB5; Eukaryota.
DR GeneTree; ENSGT00390000000220; -.
DR HOGENOM; CLU_105474_1_0_1; -.
DR InParanoid; Q66IA6; -.
DR OMA; AWPTVAW; -.
DR OrthoDB; 1296179at2759; -.
DR PhylomeDB; Q66IA6; -.
DR TreeFam; TF332443; -.
DR PRO; PR:Q66IA6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000004307; Expressed in retina and 32 other tissues.
DR GO; GO:0046658; C:anchored component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IDA:ZFIN.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central.
DR GO; GO:0030548; F:acetylcholine receptor regulator activity; IBA:GO_Central.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IGI:ZFIN.
DR GO; GO:0060827; P:regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation; IMP:ZFIN.
DR GO; GO:2000053; P:regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; IMP:ZFIN.
DR GO; GO:0060061; P:Spemann organizer formation; IMP:ZFIN.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR031574; LYPD6.
DR InterPro; IPR039457; LYPD6-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR31171; PTHR31171; 1.
DR PANTHER; PTHR31171:SF0; PTHR31171:SF0; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..174
FT /note="Ly6/PLAUR domain-containing protein 6"
FT /id="PRO_5008970952"
FT DOMAIN 47..141
FT /note="UPAR/Ly6"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 174 AA; 19585 MW; 15D60A11C09D57C3 CRC64;
MEPWPLMAWG LMLTAITGWI KAVQSRDFTE KDIIFLHPST TPYPGGFKCF TCEDAPDNYE
CNRWAPDLYC PRESRYCYTH HKMSWDGNTV SVTKRCVPLE DCLQTGCSDI DHEGNRVCTA
CCEGNICNLP LPRNETDAIF STTSPINRSA QSTQTLPLLL LSVSITSLML HSIN
