LYPD6_MOUSE
ID LYPD6_MOUSE Reviewed; 171 AA.
AC Q8BPP5;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Ly6/PLAUR domain-containing protein 6;
DE Flags: Precursor;
GN Name=Lypd6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=19403274; DOI=10.1016/j.euroneuro.2009.03.007;
RA Darvas M., Morsch M., Racz I., Ahmadi S., Swandulla D., Zimmer A.;
RT "Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by
RT Lypd6.";
RL Eur. Neuropsychopharmacol. 19:670-681(2009).
CC -!- FUNCTION: Acts as a modulator of nicotinic acetylcholine receptors
CC (nAChRs) function in the brain. Enhances nicotine-induced Ca(2+) influx
CC through nAChRs (PubMed:19403274). Acts as a positive regulator of
CC Wnt/beta-catenin signaling (By similarity).
CC {ECO:0000250|UniProtKB:Q66IA6, ECO:0000269|PubMed:19403274}.
CC -!- SUBUNIT: Interacts with nicotinic acetylcholine receptors (nAChRs)
CC including CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNB2 and CHRNB4.
CC {ECO:0000250|UniProtKB:Q86Y78}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q86Y78}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q86Y78}. Cell membrane
CC {ECO:0000250|UniProtKB:Q66IA6}; Lipid-anchor, GPI-anchor
CC {ECO:0000250|UniProtKB:Q66IA6}. Synapse, synaptosome
CC {ECO:0000250|UniProtKB:D3ZTT2}. Membrane raft
CC {ECO:0000250|UniProtKB:Q66IA6}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the brain and spinal cord, as
CC well as dorsal root and trigeminal ganglia.
CC {ECO:0000269|PubMed:19403274}.
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DR EMBL; AK053620; BAC35449.1; -; mRNA.
DR EMBL; BC070462; AAH70462.1; -; mRNA.
DR CCDS; CCDS16026.1; -.
DR RefSeq; NP_796113.1; NM_177139.5.
DR RefSeq; XP_011237418.1; XM_011239116.2.
DR AlphaFoldDB; Q8BPP5; -.
DR SMR; Q8BPP5; -.
DR STRING; 10090.ENSMUSP00000061578; -.
DR GlyGen; Q8BPP5; 2 sites.
DR PhosphoSitePlus; Q8BPP5; -.
DR PaxDb; Q8BPP5; -.
DR PRIDE; Q8BPP5; -.
DR ProteomicsDB; 252692; -.
DR Antibodypedia; 33640; 68 antibodies from 14 providers.
DR Ensembl; ENSMUST00000053208; ENSMUSP00000061578; ENSMUSG00000050447.
DR Ensembl; ENSMUST00000112712; ENSMUSP00000108332; ENSMUSG00000050447.
DR Ensembl; ENSMUST00000169232; ENSMUSP00000131002; ENSMUSG00000050447.
DR GeneID; 320343; -.
DR KEGG; mmu:320343; -.
DR UCSC; uc008jqa.3; mouse.
DR CTD; 130574; -.
DR MGI; MGI:2443848; Lypd6.
DR VEuPathDB; HostDB:ENSMUSG00000050447; -.
DR eggNOG; ENOG502RYB5; Eukaryota.
DR GeneTree; ENSGT00390000000220; -.
DR InParanoid; Q8BPP5; -.
DR OMA; AWPTVAW; -.
DR OrthoDB; 1296179at2759; -.
DR PhylomeDB; Q8BPP5; -.
DR TreeFam; TF332443; -.
DR BioGRID-ORCS; 320343; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Lypd6; mouse.
DR PRO; PR:Q8BPP5; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BPP5; protein.
DR Bgee; ENSMUSG00000050447; Expressed in renal medulla collecting duct and 187 other tissues.
DR ExpressionAtlas; Q8BPP5; baseline and differential.
DR Genevisible; Q8BPP5; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; ISO:MGI.
DR GO; GO:0030548; F:acetylcholine receptor regulator activity; IMP:UniProtKB.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR031574; LYPD6.
DR InterPro; IPR039457; LYPD6-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR31171; PTHR31171; 1.
DR PANTHER; PTHR31171:SF0; PTHR31171:SF0; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Secreted; Signal; Synapse; Synaptosome.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..171
FT /note="Ly6/PLAUR domain-containing protein 6"
FT /id="PRO_0000036179"
FT DOMAIN 47..141
FT /note="UPAR/Ly6"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 171 AA; 19065 MW; 2AF886868BDE5CC4 CRC64;
MEPSPALAWL LLLSLVADCL KAAQSRDFTV KDIIYLHPST TPYPGGFKCF TCEKAADNYE
CNRWAPDIYC PRDTRYCYTQ HTMEVTGNSI SVTKRCVPLE ECLSTGCRDS EHEGYKICTS
CCEGNICNLP LPRNETDATF ATTSPINQTN GHPHCVSVIV SCLWVWLGLT L
