LYPD6_RAT
ID LYPD6_RAT Reviewed; 171 AA.
AC D3ZTT2;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 2.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Ly6/PLAUR domain-containing protein 6;
DE Flags: Precursor;
GN Name=Lypd6;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F.,
RA Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G.,
RA Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=27344019; DOI=10.1111/jnc.13718;
RA Arvaniti M., Jensen M.M., Soni N., Wang H., Klein A.B., Thiriet N.,
RA Pinborg L.H., Muldoon P.P., Wienecke J., Imad Damaj M., Kohlmeier K.A.,
RA Gondre-Lewis M.C., Mikkelsen J.D., Thomsen M.S.;
RT "Functional interaction between Lypd6 and nicotinic acetylcholine
RT receptors.";
RL J. Neurochem. 138:806-820(2016).
CC -!- FUNCTION: Acts as a modulator of nicotinic acetylcholine receptors
CC (nAChRs) function in the brain. Enhances nicotine-induced Ca(2+) influx
CC through nAChRs (PubMed:27344019). Acts as a positive regulator of
CC Wnt/beta-catenin signaling (By similarity).
CC {ECO:0000250|UniProtKB:Q66IA6, ECO:0000269|PubMed:27344019}.
CC -!- SUBUNIT: Interacts with nicotinic acetylcholine receptors (nAChRs)
CC including CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNB2 and CHRNB4.
CC {ECO:0000250|UniProtKB:Q86Y78}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q86Y78}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q86Y78}. Membrane
CC {ECO:0000269|PubMed:27344019}. Cell membrane
CC {ECO:0000250|UniProtKB:Q66IA6}; Lipid-anchor, GPI-anchor
CC {ECO:0000250|UniProtKB:Q66IA6}. Synapse, synaptosome
CC {ECO:0000269|PubMed:27344019}. Membrane raft
CC {ECO:0000250|UniProtKB:Q66IA6}.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in the cortex and
CC cerebellum of the brain, at moderate levels in the lung, kidney, and
CC liver, and at low levels in the heart and prostate (at protein level).
CC {ECO:0000269|PubMed:27344019}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed during early development, showing
CC high levels in the first postnatal days, followed by a decrease toward
CC adulthood. {ECO:0000269|PubMed:27344019}.
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DR EMBL; AABR07052085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473983; EDM00460.1; -; Genomic_DNA.
DR EMBL; CH473983; EDM00461.1; -; Genomic_DNA.
DR RefSeq; XP_001053512.3; XM_001053512.5.
DR RefSeq; XP_003753769.1; XM_003753721.3.
DR RefSeq; XP_006224472.1; XM_006224410.3.
DR RefSeq; XP_006234222.1; XM_006234160.3.
DR RefSeq; XP_008773595.1; XM_008775373.2.
DR AlphaFoldDB; D3ZTT2; -.
DR SMR; D3ZTT2; -.
DR STRING; 10116.ENSRNOP00000056346; -.
DR GlyGen; D3ZTT2; 2 sites.
DR PaxDb; D3ZTT2; -.
DR Ensembl; ENSRNOT00000095416; ENSRNOP00000096059; ENSRNOG00000068044.
DR GeneID; 679564; -.
DR KEGG; rno:679564; -.
DR CTD; 130574; -.
DR RGD; 1587119; Lypd6.
DR eggNOG; ENOG502RYB5; Eukaryota.
DR GeneTree; ENSGT00390000000220; -.
DR HOGENOM; CLU_105474_1_0_1; -.
DR InParanoid; D3ZTT2; -.
DR OMA; AWPTVAW; -.
DR OrthoDB; 1296179at2759; -.
DR TreeFam; TF332443; -.
DR PRO; PR:D3ZTT2; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Proteomes; UP000234681; Chromosome 3.
DR Bgee; ENSRNOG00000038980; Expressed in frontal cortex and 10 other tissues.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IDA:UniProtKB.
DR GO; GO:0030548; F:acetylcholine receptor regulator activity; ISO:RGD.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR031574; LYPD6.
DR InterPro; IPR039457; LYPD6-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR31171; PTHR31171; 1.
DR PANTHER; PTHR31171:SF0; PTHR31171:SF0; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Secreted; Signal; Synapse; Synaptosome.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..171
FT /note="Ly6/PLAUR domain-containing protein 6"
FT /id="PRO_5008161185"
FT DOMAIN 47..141
FT /note="UPAR/Ly6"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 171 AA; 19051 MW; 2AF886868A754674 CRC64;
MEPSPALAWL LLLSLVADCL KAAQSRDFTV KDIIYLHPST TPYPGGFKCF TCEKAADNYE
CNRWAPDIYC PRDTRYCYTQ HTMEVTGNSI SVTKRCVPLE ECLSTGCRDS EHEGYKICTS
CCEGNICNLP LPRNDTDATF ATTSPINQTN GHPHCVSVIV SCLWVWLGLT L
