ID   LYPGN_MYCBO             Reviewed;         261 AA.
AC   P64838; A0A1R3XY82; P71669; X2BHS7;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JAN-2015, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Lysoplasmalogenase {ECO:0000250|UniProtKB:P9WG51};
DE            EC=3.3.2.2 {ECO:0000250|UniProtKB:P9WG51};
GN   OrderedLocusNames=BQ2027_MB1436;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Specifically hydrolyzes the vinyl ether bond of
CC       lysoplasmenylcholine (pLPC) and lysoplasmenylethanolamine (pLPE) to
CC       release a fatty aldehyde and glycerophospho-choline or glycerophospho-
CC       ethanolamine. {ECO:0000250|UniProtKB:P9WG51}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-
CC         saturated aldehyde + sn-glycerol 3-phosphocholine;
CC         Xref=Rhea:RHEA:22544, ChEBI:CHEBI:15377, ChEBI:CHEBI:16870,
CC         ChEBI:CHEBI:73359, ChEBI:CHEBI:77287; EC=3.3.2.2;
CC         Evidence={ECO:0000250|UniProtKB:P9WG51};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a
CC         2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine;
CC         Xref=Rhea:RHEA:16905, ChEBI:CHEBI:15377, ChEBI:CHEBI:73359,
CC         ChEBI:CHEBI:77288, ChEBI:CHEBI:143890; EC=3.3.2.2;
CC         Evidence={ECO:0000250|UniProtKB:P9WG51};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P9WG51};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM86 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=SIU00039.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; LT708304; SIU00039.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_855088.1; NC_002945.3.
DR   AlphaFoldDB; P64838; -.
DR   EnsemblBacteria; SIU00039; SIU00039; BQ2027_MB1436.
DR   PATRIC; fig|233413.5.peg.1571; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012506; YhhN.
DR   PANTHER; PTHR31885; PTHR31885; 1.
DR   Pfam; PF07947; YhhN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Lipid metabolism; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..261
FT                   /note="Lysoplasmalogenase"
FT                   /id="PRO_0000201847"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   261 AA;  27391 MW;  DFA3084579718A91 CRC64;
     MGSIAGFSSA VLSKLGIPVP YAPRLLAGGW VVAGWAGLAY GVYLTVIALR LPPGSELTGH
     AMLQPAFKAS MAVLLAAAAV AHPIGRERRW LVPALLLSAT GDWLLAIPWW TWAFVFGLGA
     FLLAHLCFIG ALLPLARQAA PSRGRVAAVV AMCVASAGLL VWFWPHLGKD NLTIPVTVYI
     VALSAMVCTA LLARLPTIWT AVGAVCFAAS DSMIGIGRFI LGNEALAVPI WWSYAAAEIL
     ITAGFFFGRE VPDNAAAPTD S