ID   LYPGN_MYCTO             Reviewed;         261 AA.
AC   P9WG50; L0T858; P64837; P71669;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   07-JAN-2015, sequence version 2.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Lysoplasmalogenase {ECO:0000250|UniProtKB:P9WG51};
DE            EC=3.3.2.2 {ECO:0000250|UniProtKB:P9WG51};
GN   OrderedLocusNames=MT1445;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Specifically hydrolyzes the vinyl ether bond of
CC       lysoplasmenylcholine (pLPC) and lysoplasmenylethanolamine (pLPE) to
CC       release a fatty aldehyde and glycerophospho-choline or glycerophospho-
CC       ethanolamine. {ECO:0000250|UniProtKB:P9WG51}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-
CC         saturated aldehyde + sn-glycerol 3-phosphocholine;
CC         Xref=Rhea:RHEA:22544, ChEBI:CHEBI:15377, ChEBI:CHEBI:16870,
CC         ChEBI:CHEBI:73359, ChEBI:CHEBI:77287; EC=3.3.2.2;
CC         Evidence={ECO:0000250|UniProtKB:P9WG51};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a
CC         2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine;
CC         Xref=Rhea:RHEA:16905, ChEBI:CHEBI:15377, ChEBI:CHEBI:73359,
CC         ChEBI:CHEBI:77288, ChEBI:CHEBI:143890; EC=3.3.2.2;
CC         Evidence={ECO:0000250|UniProtKB:P9WG51};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P9WG51};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM86 family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK45710.1; -; Genomic_DNA.
DR   PIR; F70900; F70900.
DR   AlphaFoldDB; P9WG50; -.
DR   EnsemblBacteria; AAK45710; AAK45710; MT1445.
DR   KEGG; mtc:MT1445; -.
DR   HOGENOM; CLU_079086_3_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012506; YhhN.
DR   PANTHER; PTHR31885; PTHR31885; 1.
DR   Pfam; PF07947; YhhN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Lipid metabolism; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..261
FT                   /note="Lysoplasmalogenase"
FT                   /id="PRO_0000428423"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   261 AA;  27391 MW;  DFA3084579718A91 CRC64;
     MGSIAGFSSA VLSKLGIPVP YAPRLLAGGW VVAGWAGLAY GVYLTVIALR LPPGSELTGH
     AMLQPAFKAS MAVLLAAAAV AHPIGRERRW LVPALLLSAT GDWLLAIPWW TWAFVFGLGA
     FLLAHLCFIG ALLPLARQAA PSRGRVAAVV AMCVASAGLL VWFWPHLGKD NLTIPVTVYI
     VALSAMVCTA LLARLPTIWT AVGAVCFAAS DSMIGIGRFI LGNEALAVPI WWSYAAAEIL
     ITAGFFFGRE VPDNAAAPTD S