ID   LYPL1_PONAB             Reviewed;         237 AA.
AC   Q5R8C2; Q5RB27;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Lysophospholipase-like protein 1 {ECO:0000250|UniProtKB:Q5VWZ2};
DE            EC=3.1.2.22 {ECO:0000250|UniProtKB:Q5VWZ2};
GN   Name=LYPLAL1 {ECO:0000250|UniProtKB:Q5VWZ2};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Heart, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has depalmitoylating activity toward KCNMA1. Does not exhibit
CC       phospholipase nor triacylglycerol lipase activity, able to hydrolyze
CC       only short chain substrates due to its shallow active site (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) +
CC         hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233,
CC         Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:74151; EC=3.1.2.22;
CC         Evidence={ECO:0000250|UniProtKB:Q5VWZ2};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19234;
CC         Evidence={ECO:0000250|UniProtKB:Q5VWZ2};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5R8C2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5R8C2-2; Sequence=VSP_017557;
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 2
CC       family. {ECO:0000305}.
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DR   EMBL; CR858831; CAH91033.1; -; mRNA.
DR   EMBL; CR859831; CAH91988.1; -; mRNA.
DR   RefSeq; NP_001126154.1; NM_001132682.1. [Q5R8C2-1]
DR   RefSeq; NP_001128798.1; NM_001135326.1.
DR   RefSeq; XP_009235805.1; XM_009237530.1. [Q5R8C2-1]
DR   AlphaFoldDB; Q5R8C2; -.
DR   SMR; Q5R8C2; -.
DR   STRING; 9601.ENSPPYP00000000218; -.
DR   ESTHER; ponpy-lypl1; LYsophospholipase_carboxylesterase.
DR   Ensembl; ENSPPYT00000000233; ENSPPYP00000000218; ENSPPYG00000000212. [Q5R8C2-1]
DR   GeneID; 100173113; -.
DR   GeneID; 100189704; -.
DR   KEGG; pon:100189704; -.
DR   CTD; 127018; -.
DR   eggNOG; KOG2112; Eukaryota.
DR   GeneTree; ENSGT00940000159171; -.
DR   InParanoid; Q5R8C2; -.
DR   OrthoDB; 1373549at2759; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IEA:RHEA.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR003140; PLipase/COase/thioEstase.
DR   Pfam; PF02230; Abhydrolase_2; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Cytoplasm; Hydrolase;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q5VWZ2"
FT   CHAIN           2..237
FT                   /note="Lysophospholipase-like protein 1"
FT                   /id="PRO_0000227559"
FT   ACT_SITE        124
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        179
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        211
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5VWZ2"
FT   VAR_SEQ         1..68
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_017557"
FT   CONFLICT        227
FT                   /note="T -> R (in Ref. 1; CAH91033)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   237 AA;  26299 MW;  041C69EC618BEE5B CRC64;
     MAAASASVLQ RCIVSPAGRH SASLIFLHGS GDSGQGLRMW IKQVLNQDLT FQHIKIIYPT
     APPRSYTPMK GGISNVWFDR FKITNDCPEH LESIDVMCQV LTDLIDEEVK SGIKKNRILI
     GGFSMGGSMA MHLAYRNHQD VAGVFALSSF LNKASAVYQA LQKSNGVLPE LFQCHGTADE
     LVLHSWAEET NSMLKSLGVT TKLHSFPDVY HELSKTELDI LKLWILTKLP GEMEKQK