ID   LYRA_STAAB              Reviewed;         418 AA.
AC   Q2YYX7;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Lysostaphin resistance protein A;
GN   Name=lyrA; OrderedLocusNames=SAB2212;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LyrA family. {ECO:0000305}.
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DR   EMBL; AJ938182; CAI81901.1; -; Genomic_DNA.
DR   RefSeq; WP_000794447.1; NC_007622.1.
DR   AlphaFoldDB; Q2YYX7; -.
DR   SMR; Q2YYX7; -.
DR   KEGG; sab:SAB2212; -.
DR   HOGENOM; CLU_046135_0_0_9; -.
DR   OMA; MAFFAEF; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..418
FT                   /note="Lysostaphin resistance protein A"
FT                   /id="PRO_0000274820"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          274..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        296..318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..418
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  46814 MW;  04F5440AFFF1FF9F CRC64;
     MKNNKISGFQ WAMTIFVFFV ITMALSIMLR DFQSIIGVKH FIFEVTDLAP LIAAIICILV
     FKYKKVQLAG LKFSISLKVI ERLLLALILP LIILIIGMYS FNTFADSFIL LQSTGLSVPI
     THILIGHILM AFVVEFGFRS YLQNIVETKM NTFFASIVVG LMYSVFSANT TYGTEFAAYN
     FLYTFSFSMI LGELIRATKG RTIYIATTFH ASMTFGLIFL FSEEIGDLFS IKVIAISTAI
     VAVGYIGLSL IIRGIAYLTT RRNLEELEPN NYLDHVNDDE ETNHTRAEKS SSNIKDAEKT
     GVSTASTVGI AKSDTENTVA DEPSIHEGTE KTEPQHHIDN QTESNHDEDH DITSESVESA
     ESVKHTLQSD DLTNDSNEDE KQSLKEPATY KEDRRSSVVI DAEKHIEKTE EQSSDKNK