LYRA_STAAN
ID LYRA_STAAN Reviewed; 419 AA.
AC Q7A3Z2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Lysostaphin resistance protein A;
GN Name=lyrA; OrderedLocusNames=SA2126;
OS Staphylococcus aureus (strain N315).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N315;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=N315;
RA Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT "Shotgun proteomic analysis of total and membrane protein extracts of S.
RT aureus strain N315.";
RL Submitted (OCT-2007) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LyrA family. {ECO:0000305}.
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DR EMBL; BA000018; BAB43427.1; -; Genomic_DNA.
DR PIR; B90033; B90033.
DR RefSeq; WP_000794442.1; NC_002745.2.
DR AlphaFoldDB; Q7A3Z2; -.
DR SMR; Q7A3Z2; -.
DR EnsemblBacteria; BAB43427; BAB43427; BAB43427.
DR KEGG; sau:SA2126; -.
DR HOGENOM; CLU_046135_0_0_9; -.
DR OMA; MAFFAEF; -.
DR Proteomes; UP000000751; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..419
FT /note="Lysostaphin resistance protein A"
FT /id="PRO_0000274826"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 273..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 46785 MW; D109375573B11E25 CRC64;
MKNNKISGFQ WAMTIFVFFV ITMALSIMLR DFQSIIGVKH FIFEVTDLAP LIAAIICILV
FKYKKVQLAG LKFSISLKVI ERLLLALILP LIILIIGMYS FNTFADSFIL LQSTGLSVPI
THILIGHILM AFVVEFGFRS YLQNIVETKM NTFFASIVVG LMYSVFSANT TYGTEFAAYN
FLYTFSFSMI LGELIRATKG RTIYIATTFH ASMTFGLIFL FSEEIGDLFS IKVIAISTAI
VAVGYIGLSL IIRGIAYLTT RRNLEELEPN NYLDHVNDDE ETNHTEAEKS SSNIKDAEKT
GVATASTVGV AKNDTENTVA DEPSIHEGTE KTEPQHHIGN QTESNHDEDH DITSESVESA
ESVKQAPQSD DLTNDSNEDE IEQSLKEPAT YKEDRRSSVV IDAEKHIEKT EEQSSDKNK