ID   LYRA_STAAR              Reviewed;         419 AA.
AC   Q6GEA0;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Lysostaphin resistance protein A;
GN   Name=lyrA; OrderedLocusNames=SAR2421;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LyrA family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG41401.1; -; Genomic_DNA.
DR   RefSeq; WP_000794464.1; NC_002952.2.
DR   AlphaFoldDB; Q6GEA0; -.
DR   SMR; Q6GEA0; -.
DR   KEGG; sar:SAR2421; -.
DR   HOGENOM; CLU_046135_0_0_9; -.
DR   OMA; MAFFAEF; -.
DR   OrthoDB; 1114699at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..419
FT                   /note="Lysostaphin resistance protein A"
FT                   /id="PRO_0000274822"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          273..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        273..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        296..318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..419
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   419 AA;  46901 MW;  05CAF9CBC0D7A219 CRC64;
     MKNNKISGFQ WAMTIFVFFV ITMALSIMLR DFQSVIGVKH FIFEVTDLAP LIAAIICILV
     FKYKKIQLAG LKFSISLKVI ERLLLALILP LIILIIGMYS FNTFADSFIL LQSTGLSVPI
     THILIGHILM AFVVEFGFRS YLQNIVETKM NTFFASIVVG LMYSVFSANT TYDTEFAAYN
     FLYTFSFSMI LGELIRATKG RTIYIATTFH ASMTFGLIFL FSEEIGDLFS IKVIAISTAI
     VAVGYIGLSL IIRGIAYLTT RRNLEELEPN NYLDHVNDDE ETNHTEAEKS SSNIKDAEKT
     GVATASTVGI AKNDTENTVA DEPSIHEGTE KTESQHHIDN QTESNHDEDH DITSKSVESA
     ESVKHAPQSD DLTNDSNEDE TEQSLKEPAT YKEDRRSSVV IDAEKHIEKT EEQSSDKNK