ID   LYRA_STAES              Reviewed;         382 AA.
AC   Q8CRD1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Lysostaphin resistance protein A;
GN   Name=lyrA; OrderedLocusNames=SE_1908;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LyrA family. {ECO:0000305}.
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DR   EMBL; AE015929; AAO05549.1; -; Genomic_DNA.
DR   RefSeq; NP_765463.1; NC_004461.1.
DR   RefSeq; WP_001831571.1; NZ_WBME01000027.1.
DR   AlphaFoldDB; Q8CRD1; -.
DR   SMR; Q8CRD1; -.
DR   EnsemblBacteria; AAO05549; AAO05549; SE_1908.
DR   GeneID; 50017989; -.
DR   KEGG; sep:SE_1908; -.
DR   PATRIC; fig|176280.10.peg.1867; -.
DR   eggNOG; COG1266; Bacteria.
DR   HOGENOM; CLU_046135_0_0_9; -.
DR   OMA; MAFFAEF; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0071586; P:CAAX-box protein processing; IEA:InterPro.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003675; Rce1-like.
DR   Pfam; PF02517; Rce1-like; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..382
FT                   /note="Lysostaphin resistance protein A"
FT                   /id="PRO_0000274829"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          278..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..317
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..382
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   382 AA;  43177 MW;  A651596A0890E0D5 CRC64;
     MKNSRFSGFQ WAMMVFVFFV ITMALSVILR DFQATIGVKR FVFSIKDLAP FIAAIVCILV
     FKHRKEQLAG LKFSISLKVI ERLLLALILP LIILMIGLFS FNTYADSFIL LQTSDLSVSL
     LTILIGHILM AFVVEFGFRS YLQNILETRM NTFFASIVVG LIYSVFTANT TYGVEYAGYH
     FLYTFMFSMI IGELIRATNG RTIYIATAFH ASMTFALVFL FSEETGDLFS MKVIALSTTI
     VGVSFIIISL IIRAIVYKTT KQSLDEVDPN NYLSHIQDEE PSQEDASSTS NHDVSSKDET
     KQQDIDNDKH QSKKPNKSDD ALTTSNYKED ASSVNKETDT THNDNIKDHS TYTEDRHSSV
     VNDVKDEIHE VEDHKADTDK SH