ID   LYRA_STAHJ              Reviewed;         363 AA.
AC   Q4L8J4;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Lysostaphin resistance protein A;
GN   Name=lyrA; OrderedLocusNames=SH0722;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LyrA family. {ECO:0000305}.
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DR   EMBL; AP006716; BAE04031.1; -; Genomic_DNA.
DR   RefSeq; WP_011275046.1; NC_007168.1.
DR   AlphaFoldDB; Q4L8J4; -.
DR   SMR; Q4L8J4; -.
DR   STRING; 279808.SH0722; -.
DR   EnsemblBacteria; BAE04031; BAE04031; SH0722.
DR   KEGG; sha:SH0722; -.
DR   eggNOG; COG1266; Bacteria.
DR   HOGENOM; CLU_046135_0_0_9; -.
DR   OMA; MAFFAEF; -.
DR   OrthoDB; 1114699at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0071586; P:CAAX-box protein processing; IEA:InterPro.
DR   InterPro; IPR003675; Rce1-like.
DR   Pfam; PF02517; Rce1-like; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..363
FT                   /note="Lysostaphin resistance protein A"
FT                   /id="PRO_0000274831"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          269..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..316
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  41346 MW;  377F42FDFA6F368C CRC64;
     MKTNRISGFQ WALTIFVFFV VTMALSLILR DFQASVGIKR FVFDITDLAP FIAAIVCIIA
     FKDKRTQLAG LKFSVDIRVI ERILLALILP LVIFMIGMFS FNTFADSFIL LQATDLSVSV
     PTIIIGHILM AFFAEFGFRS YLQNIVENKV NTFFASIIVG LIYSIWAANT TYGMEYAGYH
     FLYTFMFSII IGELIRATKG RTIYIALVFH ASMSFAQVFL FSEETGDLFS MKVIALSTTL
     VGIVFIILSL IIRFIVYKTT NRSLDEVEPN NYLDHMNDDD TTTSNETKSE DHEHNDKKDS
     FTESQLNEDH VELKSQSENQ TDSSNEKLKE NTSYKEDRRS SVVDDAKDEI DQMKDTSSHK
     TEK