ID   LYRA_STAS1              Reviewed;         471 AA.
AC   Q49ZR0;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Lysostaphin resistance protein A;
GN   Name=lyrA; OrderedLocusNames=SSP0569;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LyrA family. {ECO:0000305}.
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DR   EMBL; AP008934; BAE17714.1; -; Genomic_DNA.
DR   RefSeq; WP_011302517.1; NZ_MTGA01000036.1.
DR   AlphaFoldDB; Q49ZR0; -.
DR   SMR; Q49ZR0; -.
DR   STRING; 342451.SSP0569; -.
DR   EnsemblBacteria; BAE17714; BAE17714; SSP0569.
DR   KEGG; ssp:SSP0569; -.
DR   PATRIC; fig|342451.11.peg.574; -.
DR   eggNOG; COG1266; Bacteria.
DR   HOGENOM; CLU_046135_0_0_9; -.
DR   OrthoDB; 1114699at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..471
FT                   /note="Lysostaphin resistance protein A"
FT                   /id="PRO_0000274832"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          294..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..401
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..417
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..436
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   471 AA;  52891 MW;  8943441CBCFF0602 CRC64;
     MNTKRIPGFQ WAMMIFIFFI VAYALPIILK DLQSSVPFKD FVFDMSTLAP FIAAFICIAI
     FSHRGTQLAS LKLTISLKVI ERAILALILP LIIFIIAMVC FNIFSDSFVL LQTKDLSVSI
     SSIIIGQIVM AFLVELGFRS YLQHIVETKM NTFFASIIVG FMYAIWNVNI AFSFDFAIYS
     FLYSFAFSMI IGELIRATKG RTIYIATLFH FAMSFGLVFL FNEELGEVFA MKVIALSTAA
     VAILYILISL IIRTILYFFT KRNLDEVEEN NYLDHVNDTD EDLTDVGDEY NVSETDETHH
     SANVNAATAE TSSEVQDKED PTDRHHESNA SDQDNQYNST EDTAHEDDSR ANIISENTPS
     PSSNDSTKVD AKHSDSRANS AVEASTEKAH PESDQDEVKV NSRYTSNRQS SVVSDARTTI
     DEESDESSRH LSSESDDVTQ QDNQPLDTAD SSNADYERSP FDLKSKRGHR S