ID   LYRM1_HUMAN             Reviewed;         122 AA.
AC   O43325; B2R4M5;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=LYR motif-containing protein 1;
GN   Name=LYRM1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA   Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA   Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA   Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA   Adams M.D.;
RT   "Genome duplications and other features in 12 Mb of DNA sequence from human
RT   chromosome 16p and 16q.";
RL   Genomics 60:295-308(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=19022914; DOI=10.1530/eje-08-0518;
RA   Qiu J., Gao C.-L., Zhang M., Chen R.-H., Chi X., Liu F., Zhang C.-M.,
RA   Ji C.-B., Chen X.-H., Zhao Y.-P., Li X.-N., Tong M.-L., Ni Y.-H.,
RA   Guo X.-R.;
RT   "LYRM1, a novel gene promotes proliferation and inhibits apoptosis of
RT   preadipocytes.";
RL   Eur. J. Endocrinol. 160:177-184(2009).
RN   [6]
RP   POSSIBLE INVOLVEMENT IN OBESITY-ASSOCIATED INSULIN RESISTANCE.
RX   PubMed=20826099; DOI=10.1016/j.ymgme.2010.08.010;
RA   Cao X.G., Kou C.Z., Zhao Y.P., Gao C.L., Zhu C., Zhang C.M., Ji C.B.,
RA   Qin D.N., Zhang M., Guo X.R.;
RT   "Overexpression of LYRM1 induces mitochondrial impairment in 3T3-L1
RT   adipocytes.";
RL   Mol. Genet. Metab. 101:395-399(2010).
CC   -!- FUNCTION: May promote cell proliferation and inhibition of apoptosis of
CC       preadipocytes. {ECO:0000269|PubMed:19022914}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19022914}.
CC   -!- TISSUE SPECIFICITY: High levels in adipose tissue.
CC       {ECO:0000269|PubMed:19022914}.
CC   -!- DISEASE: Note=When overexpressed, may be involved in obesity-associated
CC       insulin resistance, possibly by causing mitochondrial dysfunction in
CC       adipocytes.
CC   -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
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DR   EMBL; AK311881; BAG34822.1; -; mRNA.
DR   EMBL; AC002394; AAC05810.1; -; Genomic_DNA.
DR   EMBL; CH471228; EAW66847.1; -; Genomic_DNA.
DR   EMBL; BC017039; AAH17039.1; -; mRNA.
DR   CCDS; CCDS10593.1; -.
DR   RefSeq; NP_001121773.1; NM_001128301.2.
DR   RefSeq; NP_001121774.1; NM_001128302.2.
DR   RefSeq; NP_001289764.1; NM_001302835.1.
DR   RefSeq; NP_001289765.1; NM_001302836.1.
DR   RefSeq; NP_065157.1; NM_020424.4.
DR   RefSeq; XP_005255501.1; XM_005255444.1.
DR   RefSeq; XP_016878968.1; XM_017023479.1.
DR   RefSeq; XP_016878969.1; XM_017023480.1.
DR   RefSeq; XP_016878970.1; XM_017023481.1.
DR   RefSeq; XP_016878971.1; XM_017023482.1.
DR   AlphaFoldDB; O43325; -.
DR   SMR; O43325; -.
DR   BioGRID; 121406; 9.
DR   IntAct; O43325; 7.
DR   STRING; 9606.ENSP00000379367; -.
DR   iPTMnet; O43325; -.
DR   PhosphoSitePlus; O43325; -.
DR   BioMuta; LYRM1; -.
DR   EPD; O43325; -.
DR   jPOST; O43325; -.
DR   MassIVE; O43325; -.
DR   MaxQB; O43325; -.
DR   PaxDb; O43325; -.
DR   PeptideAtlas; O43325; -.
DR   PRIDE; O43325; -.
DR   ProteomicsDB; 48905; -.
DR   Antibodypedia; 42976; 85 antibodies from 21 providers.
DR   DNASU; 57149; -.
DR   Ensembl; ENST00000219168.8; ENSP00000219168.4; ENSG00000102897.10.
DR   Ensembl; ENST00000396052.3; ENSP00000379367.2; ENSG00000102897.10.
DR   Ensembl; ENST00000439021.5; ENSP00000407883.1; ENSG00000102897.10.
DR   Ensembl; ENST00000567954.6; ENSP00000457333.1; ENSG00000102897.10.
DR   Ensembl; ENST00000568663.5; ENSP00000454826.1; ENSG00000102897.10.
DR   Ensembl; ENST00000569023.5; ENSP00000454551.1; ENSG00000102897.10.
DR   GeneID; 57149; -.
DR   KEGG; hsa:57149; -.
DR   MANE-Select; ENST00000567954.6; ENSP00000457333.1; NM_001128302.3; NP_001121774.1.
DR   UCSC; uc002dia.6; human.
DR   CTD; 57149; -.
DR   DisGeNET; 57149; -.
DR   GeneCards; LYRM1; -.
DR   HGNC; HGNC:25074; LYRM1.
DR   HPA; ENSG00000102897; Low tissue specificity.
DR   MIM; 614709; gene.
DR   neXtProt; NX_O43325; -.
DR   OpenTargets; ENSG00000102897; -.
DR   PharmGKB; PA162394735; -.
DR   VEuPathDB; HostDB:ENSG00000102897; -.
DR   eggNOG; ENOG502S1SM; Eukaryota.
DR   GeneTree; ENSGT00390000006695; -.
DR   HOGENOM; CLU_141097_0_0_1; -.
DR   InParanoid; O43325; -.
DR   OMA; KYIVQEA; -.
DR   OrthoDB; 1552235at2759; -.
DR   PhylomeDB; O43325; -.
DR   TreeFam; TF324686; -.
DR   PathwayCommons; O43325; -.
DR   SignaLink; O43325; -.
DR   BioGRID-ORCS; 57149; 16 hits in 1089 CRISPR screens.
DR   ChiTaRS; LYRM1; human.
DR   GenomeRNAi; 57149; -.
DR   Pharos; O43325; Tbio.
DR   PRO; PR:O43325; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; O43325; protein.
DR   Bgee; ENSG00000102897; Expressed in sperm and 218 other tissues.
DR   ExpressionAtlas; O43325; baseline and differential.
DR   Genevisible; O43325; HS.
DR   GO; GO:0030496; C:midbody; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   CDD; cd20261; Complex1_LYR_LYRM1; 1.
DR   InterPro; IPR008011; Complex1_LYR_dom.
DR   InterPro; IPR045294; Complex1_LYR_LYRM1.
DR   InterPro; IPR040330; LYRM1.
DR   PANTHER; PTHR14273; PTHR14273; 1.
DR   Pfam; PF05347; Complex1_LYR; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..122
FT                   /note="LYR motif-containing protein 1"
FT                   /id="PRO_0000174310"
SQ   SEQUENCE   122 AA;  14282 MW;  3A30D86F9296E82B CRC64;
     MTTATRQEVL GLYRSIFRLA RKWQATSGQM EDTIKEKQYI LNEARTLFRK NKNLTDTDLI
     KQCIDECTAR IEIGLHYKIP YPRPIHLPPM GLTPLRGRGL RSQEKLRKLS KPVYLRSHDE
     VS