5MP2_CHICK
ID 5MP2_CHICK Reviewed; 418 AA.
AC Q5ZLT7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=eIF5-mimic protein 2 {ECO:0000250|UniProtKB:Q7L1Q6};
DE AltName: Full=Basic leucine zipper and W2 domain-containing protein 1;
GN Name=BZW1; Synonyms=5MP2 {ECO:0000250|UniProtKB:Q7L1Q6};
GN ORFNames=RCJMB04_4o16;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Translation initiation regulator which may repress repeat-
CC associated non-AUG (RAN) initiated translation probably by acting as a
CC competitive inhibitor of eukaryotic translation initiation factor 5
CC (EIF5) function (By similarity). Enhances histone H4 gene transcription
CC but does not seem to bind DNA directly (By similarity).
CC {ECO:0000250|UniProtKB:Q7L1Q6}.
CC -!- SIMILARITY: Belongs to the BZW family. {ECO:0000305}.
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DR EMBL; AJ719647; CAG31306.1; -; mRNA.
DR RefSeq; NP_001006516.1; NM_001006516.1.
DR AlphaFoldDB; Q5ZLT7; -.
DR STRING; 9031.ENSGALP00000032837; -.
DR PaxDb; Q5ZLT7; -.
DR Ensembl; ENSGALT00000033478; ENSGALP00000032837; ENSGALG00000008220.
DR GeneID; 424073; -.
DR KEGG; gga:424073; -.
DR CTD; 9689; -.
DR VEuPathDB; HostDB:geneid_424073; -.
DR eggNOG; KOG2297; Eukaryota.
DR GeneTree; ENSGT00390000012561; -.
DR HOGENOM; CLU_032849_0_1_1; -.
DR InParanoid; Q5ZLT7; -.
DR OMA; KDAHMAK; -.
DR OrthoDB; 653740at2759; -.
DR PhylomeDB; Q5ZLT7; -.
DR PRO; PR:Q5ZLT7; -.
DR Proteomes; UP000000539; Chromosome 7.
DR Bgee; ENSGALG00000008220; Expressed in spermatocyte and 13 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR CDD; cd11560; W2_eIF5C_like; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR043510; W2_BZW1/2.
DR InterPro; IPR003307; W2_domain.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51363; W2; 1.
PE 2: Evidence at transcript level;
KW Activator; Reference proteome; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..418
FT /note="eIF5-mimic protein 2"
FT /id="PRO_0000254613"
FT DOMAIN 246..413
FT /note="W2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00695"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 418 AA; 48019 MW; 9A1A87182B58427B CRC64;
MNQKQQKPTL SGQRFKTRKR DEKERFDPTQ FQDCIIQGLT ETGTDLEAVA KFLDASGAKL
DYRRYAETLF DILVAGGMLA PGGTLADDMT RTDVCVFAAQ EDLETMQAFA QVFNKLIRRY
KYLEKGFEDE VKKLLLFLKG FSESERNKLA MLTGILLANG TLNASILNSL YNENLVKEGV
SAAFAVKLFK SWINEKDINA VAVSLRKVNM DNRLMELFPA NKQSVEHFSK YFTEAGLKEL
SEYVRNQQTI GARKELQKEL QEQMSRGDPF KDIILYVKEE MKKNNISEQT VIAIIWSSVM
STVEWNKKEE LVAEQAIKHL KQYSPLLAAF TTQGQSELTL LLKIQEYCYD NIHFMKAFQK
IVVLFYKAEV LSEEPILKWY KDAHLAKGKS VFLEQMKKFV EWLKNAEEES ESEAEEGD
