LYRM2_HUMAN
ID LYRM2_HUMAN Reviewed; 88 AA.
AC Q9NU23; B2R4U2; E1P517;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=LYR motif-containing protein 2;
GN Name=LYRM2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-46.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gall bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- INTERACTION:
CC Q9NU23; Q8IZU0: FAM9B; NbExp=4; IntAct=EBI-10313813, EBI-10175124;
CC -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
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DR EMBL; AK311948; BAG34889.1; -; mRNA.
DR EMBL; CH471051; EAW48547.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48549.1; -; Genomic_DNA.
DR EMBL; BC009782; AAH09782.1; -; mRNA.
DR EMBL; BC104668; AAI04669.1; -; mRNA.
DR CCDS; CCDS5023.1; -.
DR RefSeq; NP_065199.1; NM_020466.4.
DR AlphaFoldDB; Q9NU23; -.
DR SMR; Q9NU23; -.
DR BioGRID; 121461; 23.
DR IntAct; Q9NU23; 15.
DR STRING; 9606.ENSP00000430025; -.
DR iPTMnet; Q9NU23; -.
DR PhosphoSitePlus; Q9NU23; -.
DR BioMuta; LYRM2; -.
DR DMDM; 74734344; -.
DR EPD; Q9NU23; -.
DR jPOST; Q9NU23; -.
DR MassIVE; Q9NU23; -.
DR MaxQB; Q9NU23; -.
DR PaxDb; Q9NU23; -.
DR PeptideAtlas; Q9NU23; -.
DR PRIDE; Q9NU23; -.
DR ProteomicsDB; 82650; -.
DR TopDownProteomics; Q9NU23; -.
DR Antibodypedia; 54908; 124 antibodies from 23 providers.
DR DNASU; 57226; -.
DR Ensembl; ENST00000523377.2; ENSP00000430025.1; ENSG00000083099.11.
DR GeneID; 57226; -.
DR KEGG; hsa:57226; -.
DR MANE-Select; ENST00000523377.2; ENSP00000430025.1; NM_020466.5; NP_065199.1.
DR UCSC; uc003pnm.4; human.
DR CTD; 57226; -.
DR DisGeNET; 57226; -.
DR GeneCards; LYRM2; -.
DR HGNC; HGNC:25229; LYRM2.
DR HPA; ENSG00000083099; Low tissue specificity.
DR neXtProt; NX_Q9NU23; -.
DR OpenTargets; ENSG00000083099; -.
DR PharmGKB; PA162394751; -.
DR VEuPathDB; HostDB:ENSG00000083099; -.
DR eggNOG; ENOG502S8DG; Eukaryota.
DR GeneTree; ENSGT00390000002957; -.
DR HOGENOM; CLU_151409_1_1_1; -.
DR InParanoid; Q9NU23; -.
DR OMA; MMITQAS; -.
DR OrthoDB; 1575118at2759; -.
DR PhylomeDB; Q9NU23; -.
DR TreeFam; TF323797; -.
DR PathwayCommons; Q9NU23; -.
DR SignaLink; Q9NU23; -.
DR BioGRID-ORCS; 57226; 76 hits in 1083 CRISPR screens.
DR ChiTaRS; LYRM2; human.
DR GenomeRNAi; 57226; -.
DR Pharos; Q9NU23; Tdark.
DR PRO; PR:Q9NU23; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9NU23; protein.
DR Bgee; ENSG00000083099; Expressed in buccal mucosa cell and 195 other tissues.
DR ExpressionAtlas; Q9NU23; baseline and differential.
DR Genevisible; Q9NU23; HS.
DR CDD; cd20262; Complex1_LYR_LYRM2; 1.
DR InterPro; IPR008011; Complex1_LYR_dom.
DR InterPro; IPR045293; Complex1_LYR_LYRM2.
DR Pfam; PF05347; Complex1_LYR; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..88
FT /note="LYR motif-containing protein 2"
FT /id="PRO_0000251175"
FT VARIANT 34
FT /note="R -> W (in dbSNP:rs11553069)"
FT /id="VAR_050417"
FT VARIANT 46
FT /note="K -> E (in dbSNP:rs34012596)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_034099"
FT VARIANT 60
FT /note="T -> P (in dbSNP:rs1055889)"
FT /id="VAR_050418"
SQ SEQUENCE 88 AA; 10449 MW; 33F3189D286A95A0 CRC64;
MAASRLPPAT LTLKQFVRRQ QVLLLYRRIL QTIRQVPNDS DRKYLKDWAR EEFRRNKSAT
EEDTIRMMIT QGNMQLKELE KTLALAKS
