ID   LYRM4_BOVIN             Reviewed;          91 AA.
AC   Q0VCG0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=LYR motif-containing protein 4;
GN   Name=LYRM4; Synonyms=ISD11;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for nuclear and mitochondrial iron-sulfur protein
CC       biosynthesis. {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis.
CC   -!- SUBUNIT: Interacts with FXN. Interaction is increased by nickel.
CC       Interaction is inhibited by calcium, magnesium, manganese, copper,
CC       cobalt, zinc, and iron. Forms a complex with the cytosolic/nuclear form
CC       of NFS1. The complex increased the stability of NFS1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
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DR   EMBL; BC120188; AAI20189.1; -; mRNA.
DR   RefSeq; NP_001069774.1; NM_001076306.1.
DR   AlphaFoldDB; Q0VCG0; -.
DR   SMR; Q0VCG0; -.
DR   STRING; 9913.ENSBTAP00000042040; -.
DR   PaxDb; Q0VCG0; -.
DR   PRIDE; Q0VCG0; -.
DR   Ensembl; ENSBTAT00000044551; ENSBTAP00000042040; ENSBTAG00000031432.
DR   GeneID; 614011; -.
DR   KEGG; bta:614011; -.
DR   CTD; 57128; -.
DR   VEuPathDB; HostDB:ENSBTAG00000031432; -.
DR   VGNC; VGNC:31110; LYRM4.
DR   eggNOG; KOG3801; Eukaryota.
DR   GeneTree; ENSGT00940000157289; -.
DR   HOGENOM; CLU_120076_3_1_1; -.
DR   InParanoid; Q0VCG0; -.
DR   OMA; AYNYRMY; -.
DR   OrthoDB; 1561410at2759; -.
DR   TreeFam; TF323581; -.
DR   Reactome; R-BTA-1362409; Mitochondrial iron-sulfur cluster biogenesis.
DR   UniPathway; UPA00266; -.
DR   Proteomes; UP000009136; Chromosome 23.
DR   Bgee; ENSBTAG00000031432; Expressed in spermatid and 105 other tissues.
DR   GO; GO:1990221; C:L-cysteine desulfurase complex; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   CDD; cd20264; Complex1_LYR_LYRM4; 1.
DR   InterPro; IPR008011; Complex1_LYR_dom.
DR   InterPro; IPR045297; Complex1_LYR_LYRM4.
DR   Pfam; PF05347; Complex1_LYR; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Nucleus; Reference proteome.
FT   CHAIN           1..91
FT                   /note="LYR motif-containing protein 4"
FT                   /id="PRO_0000313021"
FT   MOD_RES         47
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K215"
SQ   SEQUENCE   91 AA;  10711 MW;  00D9A4229B96C7F5 CRC64;
     MAASSRAQVL DLYRAMLRES KRFGAYNYRT YAIRRIRDAF RENKNVKDPV EIQALVNKAK
     RDLGIIRRQV HIGQMYSTDK LVIENQEKPR A