ID   LYRM4_DANRE             Reviewed;          89 AA.
AC   B8JLQ0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=LYR motif-containing protein 4;
GN   Name=lyrm4; Synonyms=isd11; ORFNames=si:ch73-86n6.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Required for nuclear and mitochondrial iron-sulfur protein
CC       biosynthesis. {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
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DR   EMBL; CU469534; CAX13557.1; -; Genomic_DNA.
DR   RefSeq; NP_001157713.1; NM_001164241.1.
DR   AlphaFoldDB; B8JLQ0; -.
DR   SMR; B8JLQ0; -.
DR   STRING; 7955.ENSDARP00000103510; -.
DR   PaxDb; B8JLQ0; -.
DR   PeptideAtlas; B8JLQ0; -.
DR   Ensembl; ENSDART00000113384; ENSDARP00000103510; ENSDARG00000078352.
DR   GeneID; 100302660; -.
DR   KEGG; dre:100302660; -.
DR   CTD; 57128; -.
DR   ZFIN; ZDB-GENE-081104-295; lyrm4.
DR   eggNOG; KOG3801; Eukaryota.
DR   GeneTree; ENSGT00940000157289; -.
DR   HOGENOM; CLU_120076_3_1_1; -.
DR   InParanoid; B8JLQ0; -.
DR   OMA; AYNYRMY; -.
DR   OrthoDB; 1561410at2759; -.
DR   PhylomeDB; B8JLQ0; -.
DR   TreeFam; TF323581; -.
DR   UniPathway; UPA00266; -.
DR   PRO; PR:B8JLQ0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000078352; Expressed in muscle tissue and 28 other tissues.
DR   GO; GO:1990221; C:L-cysteine desulfurase complex; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   CDD; cd20264; Complex1_LYR_LYRM4; 1.
DR   InterPro; IPR008011; Complex1_LYR_dom.
DR   InterPro; IPR045297; Complex1_LYR_LYRM4.
DR   Pfam; PF05347; Complex1_LYR; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Nucleus; Reference proteome.
FT   CHAIN           1..89
FT                   /note="LYR motif-containing protein 4"
FT                   /id="PRO_0000370332"
SQ   SEQUENCE   89 AA;  10464 MW;  102B8CA5AE6FE319 CRC64;
     MASCSRAQVI SLYRMLMKES KKFPSYNYRT YALRRVKDGF RENLHVDNPR TLDLLINQAR
     ENLAVIKRQV SIGHLYSAQR TVVEKEPHL