ID   LYRM7_MOUSE             Reviewed;         104 AA.
AC   Q9DA03; B7ZDF8;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Complex III assembly factor LYRM7;
DE   AltName: Full=LYR motif-containing protein 7;
GN   Name=Lyrm7; Synonyms=MZM1L;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Assembly factor required for Rieske Fe-S protein UQCRFS1
CC       incorporation into the cytochrome b-c1 (CIII) complex. Functions as a
CC       chaperone, binding to this subunit within the mitochondrial matrix and
CC       stabilizing it prior to its translocation and insertion into the late
CC       CIII dimeric intermediate within the mitochondrial inner membrane (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with UQCRFS1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB24512.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK006294; BAB24512.1; ALT_INIT; mRNA.
DR   EMBL; AL954817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC139406; AAI39407.1; -; mRNA.
DR   CCDS; CCDS36154.2; -.
DR   RefSeq; NP_083603.2; NM_029327.3.
DR   AlphaFoldDB; Q9DA03; -.
DR   SMR; Q9DA03; -.
DR   BioGRID; 217552; 1.
DR   STRING; 10090.ENSMUSP00000120778; -.
DR   iPTMnet; Q9DA03; -.
DR   PhosphoSitePlus; Q9DA03; -.
DR   EPD; Q9DA03; -.
DR   MaxQB; Q9DA03; -.
DR   PaxDb; Q9DA03; -.
DR   PRIDE; Q9DA03; -.
DR   ProteomicsDB; 287280; -.
DR   Antibodypedia; 63813; 16 antibodies from 10 providers.
DR   Ensembl; ENSMUST00000144164; ENSMUSP00000120778; ENSMUSG00000020268.
DR   Ensembl; ENSMUST00000148070; ENSMUSP00000118373; ENSMUSG00000020268.
DR   GeneID; 75530; -.
DR   KEGG; mmu:75530; -.
DR   UCSC; uc011xuy.1; mouse.
DR   CTD; 90624; -.
DR   MGI; MGI:1922780; Lyrm7.
DR   VEuPathDB; HostDB:ENSMUSG00000020268; -.
DR   eggNOG; ENOG502S5FU; Eukaryota.
DR   GeneTree; ENSGT00390000017923; -.
DR   HOGENOM; CLU_147114_1_1_1; -.
DR   InParanoid; Q9DA03; -.
DR   OMA; QNRNETN; -.
DR   OrthoDB; 1585902at2759; -.
DR   PhylomeDB; Q9DA03; -.
DR   TreeFam; TF324418; -.
DR   BioGRID-ORCS; 75530; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Lyrm7; mouse.
DR   PRO; PR:Q9DA03; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q9DA03; protein.
DR   Bgee; ENSMUSG00000020268; Expressed in hindlimb stylopod muscle and 62 other tissues.
DR   ExpressionAtlas; Q9DA03; baseline and differential.
DR   Genevisible; Q9DA03; MM.
DR   GO; GO:0005759; C:mitochondrial matrix; ISO:MGI.
DR   GO; GO:0031966; C:mitochondrial membrane; ISO:MGI.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0045333; P:cellular respiration; ISO:MGI.
DR   GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISO:MGI.
DR   CDD; cd20267; Complex1_LYR_LYRM7; 1.
DR   InterPro; IPR008011; Complex1_LYR_dom.
DR   InterPro; IPR045298; Complex1_LYR_LYRM7.
DR   Pfam; PF05347; Complex1_LYR; 1.
PE   3: Inferred from homology;
KW   Chaperone; Mitochondrion; Phosphoprotein; Reference proteome.
FT   CHAIN           1..104
FT                   /note="Complex III assembly factor LYRM7"
FT                   /id="PRO_0000251180"
FT   MOD_RES         60
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5U5X0"
SQ   SEQUENCE   104 AA;  12047 MW;  DA3223FCC21B3517 CRC64;
     MGQPAKVLQL FKTLHRTRQQ VFKNDKRALE AARVKINEEF KKHKNETSPE KIKEMMKLGS
     DVELLLRTAV IQGIHTDHDT LQLVPRKDLL TENVPYCDAP TQKQ