LYS3_CAEEL
ID LYS3_CAEEL Reviewed; 301 AA.
AC Q9XXS1;
DT 09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Lysozyme-like protein 3 {ECO:0000312|WormBase:Y22F5A.6};
DE Flags: Precursor;
GN Name=lys-3 {ECO:0000312|WormBase:Y22F5A.6};
GN Synonyms=kreg-2 {ECO:0000303|PubMed:23437011};
GN ORFNames=Y22F5A.6 {ECO:0000312|WormBase:Y22F5A.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, INDUCTION BY COPPER IONS, AND DISRUPTION PHENOTYPE.
RX PubMed=23437011; DOI=10.1371/journal.pgen.1003315;
RA Hattori A., Mizuno T., Akamatsu M., Hisamoto N., Matsumoto K.;
RT "The Caenorhabditis elegans JNK signaling pathway activates expression of
RT stress response genes by derepressing the Fos/HDAC repressor complex.";
RL PLoS Genet. 9:E1003315-E1003315(2013).
CC -!- FUNCTION: Plays a role in the stress response to heavy metals such as
CC copper, probably in a kgb-1-dependent manner.
CC {ECO:0000269|PubMed:23437011}.
CC -!- INDUCTION: By heavy metal stress conditions, in response to Cu(2+).
CC {ECO:0000269|PubMed:23437011}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in partial
CC sensitivity to Cu(2+) ions with less than 70% of animals reaching
CC adulthood 4 days after egg laying. {ECO:0000269|PubMed:23437011}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 25 family.
CC {ECO:0000255|PROSITE-ProRule:PRU01252}.
CC -!- CAUTION: Weak similarity to other lysozymes and lacks the conserved
CC active site. {ECO:0000305}.
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DR EMBL; BX284605; CAA16319.1; -; Genomic_DNA.
DR PIR; T26550; T26550.
DR RefSeq; NP_505644.1; NM_073243.3.
DR AlphaFoldDB; Q9XXS1; -.
DR SMR; Q9XXS1; -.
DR STRING; 6239.Y22F5A.6; -.
DR PaxDb; Q9XXS1; -.
DR PeptideAtlas; Q9XXS1; -.
DR EnsemblMetazoa; Y22F5A.6.1; Y22F5A.6.1; WBGene00003092.
DR GeneID; 179430; -.
DR KEGG; cel:CELE_Y22F5A.6; -.
DR UCSC; Y22F5A.6; c. elegans.
DR CTD; 179430; -.
DR WormBase; Y22F5A.6; CE20201; WBGene00003092; lys-3.
DR eggNOG; ENOG502S5RB; Eukaryota.
DR GeneTree; ENSGT00970000195882; -.
DR HOGENOM; CLU_073372_1_0_1; -.
DR InParanoid; Q9XXS1; -.
DR OMA; FYDWLEI; -.
DR OrthoDB; 1437716at2759; -.
DR PhylomeDB; Q9XXS1; -.
DR PRO; PR:Q9XXS1; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003092; Expressed in adult organism and 1 other tissue.
DR GO; GO:0003796; F:lysozyme activity; IEA:InterPro.
DR GO; GO:0016998; P:cell wall macromolecule catabolic process; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:1990169; P:stress response to copper ion; IMP:WormBase.
DR InterPro; IPR002053; Glyco_hydro_25.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR SUPFAM; SSF51445; SSF51445; 1.
DR PROSITE; PS51904; GLYCOSYL_HYDROL_F25_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Signal; Stress response.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..301
FT /note="Lysozyme-like protein 3"
FT /id="PRO_5004336832"
FT DOMAIN 64..282
FT /note="Ch-type lysozyme"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"
SQ SEQUENCE 301 AA; 33784 MW; 4934CB37B90D5F6D CRC64;
MKLFALLVSI TLCYSFPAPL QTNVSEPFGL LQKVSEQVID PDYNIPEVKD APAIPYDERN
SPTHAYSVDI SFHTTPSDMD CLRDQGYKSV FVRALNPIGN TYFDRNALNT INNAFEAGLG
SEVYITPNIN STRSGADQIS LVYQNLLANG INVRSIWIQV TSPTNWVAPM AVRIEFIQDM
IRSAKNLGLS VGIYTSFYDW LEITGGWNTF SSDVFLWYWH VLSMGTDGET TPTLEDFRPF
GPWRQATVKQ FGQVEKLCGM IVNRNVYSTG NQHLSQIVHF STHQENSSSE KKLIRVGGIG
F