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LYS3_CAEEL
ID   LYS3_CAEEL              Reviewed;         301 AA.
AC   Q9XXS1;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Lysozyme-like protein 3 {ECO:0000312|WormBase:Y22F5A.6};
DE   Flags: Precursor;
GN   Name=lys-3 {ECO:0000312|WormBase:Y22F5A.6};
GN   Synonyms=kreg-2 {ECO:0000303|PubMed:23437011};
GN   ORFNames=Y22F5A.6 {ECO:0000312|WormBase:Y22F5A.6};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, INDUCTION BY COPPER IONS, AND DISRUPTION PHENOTYPE.
RX   PubMed=23437011; DOI=10.1371/journal.pgen.1003315;
RA   Hattori A., Mizuno T., Akamatsu M., Hisamoto N., Matsumoto K.;
RT   "The Caenorhabditis elegans JNK signaling pathway activates expression of
RT   stress response genes by derepressing the Fos/HDAC repressor complex.";
RL   PLoS Genet. 9:E1003315-E1003315(2013).
CC   -!- FUNCTION: Plays a role in the stress response to heavy metals such as
CC       copper, probably in a kgb-1-dependent manner.
CC       {ECO:0000269|PubMed:23437011}.
CC   -!- INDUCTION: By heavy metal stress conditions, in response to Cu(2+).
CC       {ECO:0000269|PubMed:23437011}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in partial
CC       sensitivity to Cu(2+) ions with less than 70% of animals reaching
CC       adulthood 4 days after egg laying. {ECO:0000269|PubMed:23437011}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 25 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01252}.
CC   -!- CAUTION: Weak similarity to other lysozymes and lacks the conserved
CC       active site. {ECO:0000305}.
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DR   EMBL; BX284605; CAA16319.1; -; Genomic_DNA.
DR   PIR; T26550; T26550.
DR   RefSeq; NP_505644.1; NM_073243.3.
DR   AlphaFoldDB; Q9XXS1; -.
DR   SMR; Q9XXS1; -.
DR   STRING; 6239.Y22F5A.6; -.
DR   PaxDb; Q9XXS1; -.
DR   PeptideAtlas; Q9XXS1; -.
DR   EnsemblMetazoa; Y22F5A.6.1; Y22F5A.6.1; WBGene00003092.
DR   GeneID; 179430; -.
DR   KEGG; cel:CELE_Y22F5A.6; -.
DR   UCSC; Y22F5A.6; c. elegans.
DR   CTD; 179430; -.
DR   WormBase; Y22F5A.6; CE20201; WBGene00003092; lys-3.
DR   eggNOG; ENOG502S5RB; Eukaryota.
DR   GeneTree; ENSGT00970000195882; -.
DR   HOGENOM; CLU_073372_1_0_1; -.
DR   InParanoid; Q9XXS1; -.
DR   OMA; FYDWLEI; -.
DR   OrthoDB; 1437716at2759; -.
DR   PhylomeDB; Q9XXS1; -.
DR   PRO; PR:Q9XXS1; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003092; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0003796; F:lysozyme activity; IEA:InterPro.
DR   GO; GO:0016998; P:cell wall macromolecule catabolic process; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   GO; GO:1990169; P:stress response to copper ion; IMP:WormBase.
DR   InterPro; IPR002053; Glyco_hydro_25.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS51904; GLYCOSYL_HYDROL_F25_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Signal; Stress response.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..301
FT                   /note="Lysozyme-like protein 3"
FT                   /id="PRO_5004336832"
FT   DOMAIN          64..282
FT                   /note="Ch-type lysozyme"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"
SQ   SEQUENCE   301 AA;  33784 MW;  4934CB37B90D5F6D CRC64;
     MKLFALLVSI TLCYSFPAPL QTNVSEPFGL LQKVSEQVID PDYNIPEVKD APAIPYDERN
     SPTHAYSVDI SFHTTPSDMD CLRDQGYKSV FVRALNPIGN TYFDRNALNT INNAFEAGLG
     SEVYITPNIN STRSGADQIS LVYQNLLANG INVRSIWIQV TSPTNWVAPM AVRIEFIQDM
     IRSAKNLGLS VGIYTSFYDW LEITGGWNTF SSDVFLWYWH VLSMGTDGET TPTLEDFRPF
     GPWRQATVKQ FGQVEKLCGM IVNRNVYSTG NQHLSQIVHF STHQENSSSE KKLIRVGGIG
     F
 
 
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