ID   LYSC2_HORSE             Reviewed;          33 AA.
AC   P81710;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   23-FEB-2022, entry version 72.
DE   RecName: Full=Lysozyme C, spleen isozyme;
DE            EC=3.2.1.17;
DE   AltName: Full=1,4-beta-N-acetylmuramidase C;
DE   Flags: Fragment;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Spleen;
RX   PubMed=8080284; DOI=10.1006/abbi.1994.1399;
RA   Grobler J.A., Rao K.R., Pervaiz S., Brew K.;
RT   "Sequences of two highly divergent canine type c lysozymes: implications
RT   for the evolutionary origins of the lysozyme/alpha-lactalbumin
RT   superfamily.";
RL   Arch. Biochem. Biophys. 313:360-366(1994).
CC   -!- FUNCTION: Lysozymes have primarily a bacteriolytic function; those in
CC       tissues and body fluids are associated with the monocyte-macrophage
CC       system and enhance the activity of immunoagents. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC         acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC         between N-acetyl-D-glucosamine residues in chitodextrins.;
CC         EC=3.2.1.17;
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Lysozyme C is capable of both hydrolysis and
CC       transglycosylation; it shows also a slight esterase activity. It acts
CC       rapidly on both peptide-substituted and unsubstituted peptidoglycan,
CC       and slowly on chitin oligosaccharides (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family. {ECO:0000305}.
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DR   STRING; 9796.ENSECAP00000015931; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0003796; F:lysozyme activity; IEA:UniProtKB-EC.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001916; Glyco_hydro_22.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   Pfam; PF00062; Lys; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   1: Evidence at protein level;
KW   Antimicrobial; Bacteriolytic enzyme; Direct protein sequencing;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..>33
FT                   /note="Lysozyme C, spleen isozyme"
FT                   /id="PRO_0000208852"
FT   NON_TER         33
SQ   SEQUENCE   33 AA;  3746 MW;  7B5B8B640E5F1F94 CRC64;
     KVFERXELAR TLKRLGLDGF RGVSLPNXVX LAR