LYSCN_BOVIN
ID LYSCN_BOVIN Reviewed; 148 AA.
AC P80189; Q29447; Q2KIL2;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 4.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Lysozyme C, non-stomach isozyme;
DE EC=3.2.1.17;
DE AltName: Full=1,4-beta-N-acetylmuramidase C;
DE Flags: Precursor;
GN Name=LYS; Synonyms=LZ;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Trachea;
RX PubMed=8262986; DOI=10.1016/s0021-9258(19)74267-7;
RA Takeuchi K., Irwin D.M., Gallup M., Shinbrot E., Kai H., Stewart C.B.,
RA Basbaum C.;
RT "Multiple cDNA sequences of bovine tracheal lysozyme.";
RL J. Biol. Chem. 268:27440-27446(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Deutsche Schwarzbunte; TISSUE=Blood;
RX PubMed=8921904; DOI=10.1016/0378-1119(96)00352-6;
RA Henke M., Hobom G., Senft B., Seyfert H.-M.;
RT "Structural deviations in a bovine low expression lysozyme-encoding gene
RT active in tissues other than stomach.";
RL Gene 178:131-137(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7894180; DOI=10.1007/bf00292034;
RA Brunner R.M., Henke M., Guerin G., Goldammer T., Seyfert H.M., Schwerin M.;
RT "The macrophage expressed variant of the bovine lysozyme-encoding gene maps
RT to chromosome 5q23.";
RL Mamm. Genome 5:834-834(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Kidney;
RX PubMed=8477739; DOI=10.1111/j.1432-1033.1993.tb17805.x;
RA Ito Y., Yamada H., Nakamura M., Yoshikawa A., Ueda T., Imoto T.;
RT "The primary structures and properties of non-stomach lysozymes of sheep
RT and cow, and implication for functional divergence of lysozyme.";
RL Eur. J. Biochem. 213:649-658(1993).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-148.
RC TISSUE=Granulocyte, and Mammary gland;
RX PubMed=8206386; DOI=10.1016/0378-1119(94)90109-0;
RA Steinhoff U.M., Senft B., Seyfert H.-M.;
RT "Lysozyme-encoding bovine cDNAs from neutrophile granulocytes and mammary
RT gland are derived from a different gene than stomach lysozymes.";
RL Gene 143:271-276(1994).
CC -!- FUNCTION: Lysozymes have primarily a bacteriolytic function; those in
CC tissues and body fluids are associated with the monocyte-macrophage
CC system and enhance the activity of immunoagents.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC between N-acetyl-D-glucosamine residues in chitodextrins.;
CC EC=3.2.1.17;
CC -!- TISSUE SPECIFICITY: Expressed in blood cells.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00680}.
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DR EMBL; L23757; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; U25810; AAC48683.1; -; Genomic_DNA.
DR EMBL; BC112597; AAI12598.1; -; mRNA.
DR EMBL; L19980; AAA99863.1; -; mRNA.
DR PIR; C49315; C49315.
DR RefSeq; NP_001071627.1; NM_001078159.1.
DR AlphaFoldDB; P80189; -.
DR SMR; P80189; -.
DR STRING; 9913.ENSBTAP00000038081; -.
DR CAZy; GH22; Glycoside Hydrolase Family 22.
DR PaxDb; P80189; -.
DR PeptideAtlas; P80189; -.
DR PRIDE; P80189; -.
DR Ensembl; ENSBTAT00000038266; ENSBTAP00000038081; ENSBTAG00000026779.
DR GeneID; 777776; -.
DR KEGG; bta:777776; -.
DR CTD; 4069; -.
DR VEuPathDB; HostDB:ENSBTAG00000026779; -.
DR eggNOG; ENOG502S1S1; Eukaryota.
DR GeneTree; ENSGT00940000153832; -.
DR HOGENOM; CLU_111620_0_1_1; -.
DR InParanoid; P80189; -.
DR OMA; RINCSAF; -.
DR OrthoDB; 1551203at2759; -.
DR TreeFam; TF324882; -.
DR BRENDA; 3.2.1.17; 908.
DR Reactome; R-BTA-6798695; Neutrophil degranulation.
DR Reactome; R-BTA-6803157; Antimicrobial peptides.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000026779; Expressed in monocyte and 103 other tissues.
DR ExpressionAtlas; P80189; baseline and differential.
DR GO; GO:0003796; F:lysozyme activity; IBA:GO_Central.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR019799; Glyco_hydro_22_CS.
DR InterPro; IPR000974; Glyco_hydro_22_lys.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR030056; Lysozyme_C.
DR PANTHER; PTHR11407; PTHR11407; 1.
DR PANTHER; PTHR11407:SF28; PTHR11407:SF28; 1.
DR Pfam; PF00062; Lys; 1.
DR PRINTS; PR00137; LYSOZYME.
DR PRINTS; PR00135; LYZLACT.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF53955; SSF53955; 1.
DR PROSITE; PS00128; GLYCOSYL_HYDROL_F22_1; 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
PE 2: Evidence at transcript level;
KW Antimicrobial; Bacteriolytic enzyme; Disulfide bond; Glycosidase;
KW Hydrolase; Reference proteome; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..148
FT /note="Lysozyme C, non-stomach isozyme"
FT /id="PRO_0000018458"
FT DOMAIN 19..148
FT /note="C-type lysozyme"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT ACT_SITE 53
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT ACT_SITE 71
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 24..146
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 48..134
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 83..99
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 95..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT CONFLICT 114
FT /note="A -> T (in Ref. 2 and 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 117
FT /note="V -> D (in Ref. 2 and 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 148 AA; 16476 MW; 707A79AA7FDA4FAC CRC64;
MKALLILGLL LFSVAVQGKV FERCELARSL KRFGMDNFRG ISLANWMCLA RWESNYNTQA
TNYNAGDQST DYGIFQINSH WWCNDGKTPG AVNACHLPCG ALLQDDITQA VACAKRVVSD
PQGIRAWVAW RSHCQNQDLT SYIQGCGV
