ID   LYSC_DICDI              Reviewed;         181 AA.
AC   Q8T1G5; Q554H1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Lysozyme C;
DE            EC=3.2.1.17;
DE   AltName: Full=1,4-beta-N-acetylmuramidase C;
DE   Flags: Precursor;
GN   Name=alyC; ORFNames=DDB_G0275121;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC         acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC         between N-acetyl-D-glucosamine residues in chitodextrins.;
CC         EC=3.2.1.17;
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle lumen {ECO:0000250}.
CC   -!- PTM: Contains six disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dictyostelium lysozyme family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000013; EAL69841.1; -; Genomic_DNA.
DR   RefSeq; XP_643740.1; XM_638648.1.
DR   AlphaFoldDB; Q8T1G5; -.
DR   PaxDb; Q8T1G5; -.
DR   EnsemblProtists; EAL69841; EAL69841; DDB_G0275121.
DR   GeneID; 8619784; -.
DR   KEGG; ddi:DDB_G0275121; -.
DR   dictyBase; DDB_G0275121; alyC.
DR   eggNOG; ENOG502RCK0; Eukaryota.
DR   HOGENOM; CLU_1491704_0_0_1; -.
DR   InParanoid; Q8T1G5; -.
DR   PhylomeDB; Q8T1G5; -.
DR   PRO; PR:Q8T1G5; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR   GO; GO:0060205; C:cytoplasmic vesicle lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0031983; C:vesicle lumen; ISS:UniProtKB.
DR   GO; GO:0003796; F:lysozyme activity; ISS:UniProtKB.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0009253; P:peptidoglycan catabolic process; IC:dictyBase.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Bacteriolytic enzyme; Cytoplasmic vesicle;
KW   Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..138
FT                   /note="Lysozyme C"
FT                   /id="PRO_0000315918"
FT   PROPEP          139..181
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000315919"
SQ   SEQUENCE   181 AA;  19752 MW;  6160694D7857939C CRC64;
     MRIAFFLLIL SIIVGLAYGY SCPKPCYGNM CCSTSPDHKY YLTDFCGSTS ACGPKPSCSG
     KLYFTADSQR FGCGKHLNLC RGKKCVKAKV YDAGPAEWVE KDAGKMIIDA SPTICHELTG
     GSSCGWSDKF EITATVTSLT DSRPLGPFNV TEEEMDQLFI DHEIAMAQCE AEKTCNGFDL
     E