LYSD_DICDI
ID LYSD_DICDI Reviewed; 260 AA.
AC Q556Y7; Q86JT4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Lysozyme D;
DE EC=3.2.1.17;
DE AltName: Full=1,4-beta-N-acetylmuramidase D;
DE Flags: Precursor;
GN Name=alyD-1; ORFNames=DDB_G0273197;
GN and
GN Name=alyD-2; ORFNames=DDB_G0273731;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000312|EMBL:EAL70556.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250|UniProtKB:Q554H2}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC between N-acetyl-D-glucosamine residues in chitodextrins.;
CC EC=3.2.1.17;
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle lumen
CC {ECO:0000250|UniProtKB:Q554H2}.
CC -!- PTM: Contains disulfide bonds. {ECO:0000250|UniProtKB:Q554H2}.
CC -!- SIMILARITY: Belongs to the dictyostelium lysozyme family.
CC {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70556.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70816.1; -; Genomic_DNA.
DR RefSeq; XP_644482.1; XM_639390.1.
DR RefSeq; XP_644768.1; XM_639676.1.
DR AlphaFoldDB; Q556Y7; -.
DR PaxDb; Q556Y7; -.
DR EnsemblProtists; EAL70556; EAL70556; DDB_G0273731.
DR EnsemblProtists; EAL70816; EAL70816; DDB_G0273197.
DR GeneID; 8618870; -.
DR GeneID; 8619106; -.
DR KEGG; ddi:DDB_G0273197; -.
DR KEGG; ddi:DDB_G0273731; -.
DR dictyBase; DDB_G0273197; alyD-1.
DR dictyBase; DDB_G0273731; alyD-2.
DR eggNOG; ENOG502RD7J; Eukaryota.
DR HOGENOM; CLU_1071285_0_0_1; -.
DR InParanoid; Q556Y7; -.
DR OMA; FCDESTA; -.
DR PhylomeDB; Q556Y7; -.
DR PRO; PR:Q556Y7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0060205; C:cytoplasmic vesicle lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0031983; C:vesicle lumen; ISS:UniProtKB.
DR GO; GO:0003796; F:lysozyme activity; ISS:UniProtKB.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IC:dictyBase.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Bacteriolytic enzyme; Cytoplasmic vesicle;
KW Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000250|UniProtKB:Q554H2"
FT CHAIN 20..260
FT /note="Lysozyme D"
FT /evidence="ECO:0000250|UniProtKB:Q554H2"
FT /id="PRO_0000315920"
FT REGION 83..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 260 AA; 26057 MW; 8A118309949B6010 CRC64;
MRLLVTLILL IFVLTVSGQY SCSNPCYGNM CCSIPSNNEY YLTTFCDEST ACGTPCSAQT
YFTADSQRFG CGVTLTICST SGGSTTTGGT GSAGTSTSSG SGSGSGSGSG SGSGSGSGTS
GSSSSGSSSG SGSGSSSGSG GSSGSGSGST METGGFYGVC VKAITIDAGP NISVEEEAGM
AIIDASSQIC QDLFGSSSCG WSDKRSITAV QSSVEDGFPV NKPFNVTFED YNKIISNSLI
LDQQCSNKNN CKYNKLELMK
