ID   LYSE_CORDI              Reviewed;         228 AA.
AC   Q6NHP1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Lysine exporter LysE {ECO:0000250|UniProtKB:P94633};
GN   Name=lysE; OrderedLocusNames=DIP1091;
OS   Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype
OS   gravis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=257309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700971 / NCTC 13129 / Biotype gravis;
RX   PubMed=14602910; DOI=10.1093/nar/gkg874;
RA   Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G.,
RA   Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D.,
RA   De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N.,
RA   Holroyd S., Jagels K., Moule S., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G.,
RA   Parkhill J.;
RT   "The complete genome sequence and analysis of Corynebacterium diphtheriae
RT   NCTC13129.";
RL   Nucleic Acids Res. 31:6516-6523(2003).
CC   -!- FUNCTION: Catalyzes the efflux of L-lysine.
CC       {ECO:0000250|UniProtKB:P94633}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P94633}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC       {ECO:0000305}.
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DR   EMBL; BX248357; CAE49614.1; -; Genomic_DNA.
DR   RefSeq; WP_010934800.1; NC_002935.2.
DR   AlphaFoldDB; Q6NHP1; -.
DR   STRING; 257309.DIP1091; -.
DR   EnsemblBacteria; CAE49614; CAE49614; DIP1091.
DR   KEGG; cdi:DIP1091; -.
DR   HOGENOM; CLU_087840_0_0_11; -.
DR   OMA; FARPRAW; -.
DR   OrthoDB; 1953934at2; -.
DR   Proteomes; UP000002198; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001123; LeuE-type.
DR   PANTHER; PTHR30086; PTHR30086; 2.
DR   Pfam; PF01810; LysE; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..228
FT                   /note="Lysine exporter LysE"
FT                   /id="PRO_0000204155"
FT   TRANSMEM        4..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   228 AA;  24662 MW;  6C5AAD0D7CB3ADEF CRC64;
     MSIAIAGFLM GLSLIVAIGP QNALIIRQGI KREGLIPILV VCILSDVILI FGGTAGVGAL
     VDRAPIALVV LKWLGVAYLL YFGFTCFKEA FKRHGQALAV EQSEPVAYEP VADASSGVIT
     KTRTKAQPKS AQRTWVKPVL AALAFTWLNP AAYIDVLVML GGIANQHGPD GRWVFALGAL
     CASLTWFPFI GYTSTRFSTV LSRPAVWRYI NIAIGIIMMI MCARLIMH