LYSE_COREF
ID LYSE_COREF Reviewed; 228 AA.
AC Q8RQM4;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-2002, sequence version 2.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Lysine exporter LysE {ECO:0000250|UniProtKB:P94633};
GN Name=lysE; OrderedLocusNames=CE1357;
OS Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS / NBRC 100395).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=196164;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RA Itaya H., Kimura E., Kawahara Y., Sugimoto S.;
RT "lysG, lysE of Corynebacterium efficiens.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX PubMed=12840036; DOI=10.1101/gr.1285603;
RA Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT "Comparative complete genome sequence analysis of the amino acid
RT replacements responsible for the thermostability of Corynebacterium
RT efficiens.";
RL Genome Res. 13:1572-1579(2003).
CC -!- FUNCTION: Catalyzes the efflux of L-lysine.
CC {ECO:0000250|UniProtKB:P94633}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P94633}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB88827.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC18167.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB083133; BAB88827.1; ALT_INIT; Genomic_DNA.
DR EMBL; BA000035; BAC18167.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_006769321.1; NC_004369.1.
DR AlphaFoldDB; Q8RQM4; -.
DR STRING; 196164.23493196; -.
DR EnsemblBacteria; BAC18167; BAC18167; BAC18167.
DR KEGG; cef:CE1357; -.
DR eggNOG; COG1279; Bacteria.
DR HOGENOM; CLU_087840_0_0_11; -.
DR OrthoDB; 1953934at2; -.
DR Proteomes; UP000001409; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR001123; LeuE-type.
DR InterPro; IPR004777; Lys/arg_exporter.
DR PANTHER; PTHR30086; PTHR30086; 2.
DR Pfam; PF01810; LysE; 1.
DR TIGRFAMs; TIGR00948; 2a75; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..228
FT /note="Lysine exporter LysE"
FT /id="PRO_0000204156"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 228 AA; 24374 MW; 68FB379A8380EDA7 CRC64;
MEIFVTGLLL GASLLLAIGP QNVLVIKQGI KREGITAVII VCLLSDVVLF TLGTLGVGLI
SDTAPIILDI LRWCGIAYLL WFAVMAARDA LRARTEVTFV EHSEPVAAAS ASGGGVTTKQ
RPRLRITSGT RQVWVRPMLM AIVLTWLNPN AYLDAFVFIG GVGAQYGETG RWIFAAGAFA
ASLVWFPLVG YGAAALSRPL SSPRVWRWIN IGVAVVLTGL AVKLILMG
