ID   LYSE_MYCBO              Reviewed;         199 AA.
AC   P64904; A0A1R3Y1Z7; Q10871; X2BJH6;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Lysine exporter LysE {ECO:0000250|UniProtKB:P94633};
GN   Name=lysE {ECO:0000250|UniProtKB:P9WK31}; OrderedLocusNames=BQ2027_MB2008;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Catalyzes the efflux of L-lysine.
CC       {ECO:0000250|UniProtKB:P94633}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIU00614.1; -; Genomic_DNA.
DR   RefSeq; NP_855658.1; NC_002945.3.
DR   RefSeq; WP_003409989.1; NC_002945.4.
DR   AlphaFoldDB; P64904; -.
DR   EnsemblBacteria; SIU00614; SIU00614; BQ2027_MB2008.
DR   GeneID; 45425965; -.
DR   PATRIC; fig|233413.5.peg.2206; -.
DR   OMA; FARPRAW; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001123; LeuE-type.
DR   InterPro; IPR004777; Lys/arg_exporter.
DR   PANTHER; PTHR30086; PTHR30086; 1.
DR   Pfam; PF01810; LysE; 1.
DR   TIGRFAMs; TIGR00948; 2a75; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..199
FT                   /note="Lysine exporter LysE"
FT                   /id="PRO_0000103917"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   199 AA;  20776 MW;  6F330132DDCFD0FF CRC64;
     MNSPLVVGFL ACFTLIAAIG AQNAFVLRQG IQREHVLPVV ALCTVSDIVL IAAGIAGFGA
     LIGAHPRALN VVKFGGAAFL IGYGLLAARR AWRPVALIPS GATPVRLAEV LVTCAAFTFL
     NPHVYLDTVV LLGALANEHS DQRWLFGLGA VTASAVWFAT LGFGAGRLRG LFTNPGSWRI
     LDGLIAVMMV ALGISLTVT