ID   LYSE_MYCTU              Reviewed;         199 AA.
AC   P9WK31; L0T9U8; P64903; Q10871;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Lysine exporter LysE {ECO:0000250|UniProtKB:P94633};
GN   Name=lysE {ECO:0000303|PubMed:29049397}; OrderedLocusNames=Rv1986;
GN   ORFNames=MTCY39.33c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=29049397; DOI=10.1371/journal.pone.0186505;
RA   Schneefeld M., Busche T., Geffers R., Kalinowski J., Bange F.C.;
RT   "The transcriptional regulator LysG (Rv1985c) of Mycobacterium tuberculosis
RT   activates lysE (Rv1986) in a lysine-dependent manner.";
RL   PLoS ONE 12:E0186505-E0186505(2017).
CC   -!- FUNCTION: Catalyzes the efflux of L-lysine.
CC       {ECO:0000250|UniProtKB:P94633}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Positively regulated by LysG in the presence of lysine or
CC       histidine. {ECO:0000269|PubMed:29049397}.
CC   -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44756.1; -; Genomic_DNA.
DR   PIR; H70756; H70756.
DR   RefSeq; NP_216502.1; NC_000962.3.
DR   RefSeq; WP_003409989.1; NZ_NVQJ01000043.1.
DR   AlphaFoldDB; P9WK31; -.
DR   STRING; 83332.Rv1986; -.
DR   PaxDb; P9WK31; -.
DR   DNASU; 885635; -.
DR   GeneID; 45425965; -.
DR   GeneID; 885635; -.
DR   KEGG; mtu:Rv1986; -.
DR   TubercuList; Rv1986; -.
DR   eggNOG; COG1279; Bacteria.
DR   OMA; FARPRAW; -.
DR   PhylomeDB; P9WK31; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR   InterPro; IPR001123; LeuE-type.
DR   InterPro; IPR004777; Lys/arg_exporter.
DR   PANTHER; PTHR30086; PTHR30086; 1.
DR   Pfam; PF01810; LysE; 1.
DR   TIGRFAMs; TIGR00948; 2a75; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..199
FT                   /note="Lysine exporter LysE"
FT                   /id="PRO_0000103916"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   199 AA;  20776 MW;  6F330132DDCFD0FF CRC64;
     MNSPLVVGFL ACFTLIAAIG AQNAFVLRQG IQREHVLPVV ALCTVSDIVL IAAGIAGFGA
     LIGAHPRALN VVKFGGAAFL IGYGLLAARR AWRPVALIPS GATPVRLAEV LVTCAAFTFL
     NPHVYLDTVV LLGALANEHS DQRWLFGLGA VTASAVWFAT LGFGAGRLRG LFTNPGSWRI
     LDGLIAVMMV ALGISLTVT