LYSG2_DICDI
ID LYSG2_DICDI Reviewed; 212 AA.
AC Q86KC1; Q554N9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Probable GH family 25 lysozyme 2;
DE EC=3.2.1.17;
DE AltName: Full=1,4-beta-N-acetylmuramidase 2;
DE Flags: Precursor;
GN ORFNames=DDB_G0274181;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC between N-acetyl-D-glucosamine residues in chitodextrins.;
CC EC=3.2.1.17;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 25 family.
CC {ECO:0000255|PROSITE-ProRule:PRU01252, ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000012; EAL69983.1; -; Genomic_DNA.
DR RefSeq; XP_644284.1; XM_639192.1.
DR AlphaFoldDB; Q86KC1; -.
DR SMR; Q86KC1; -.
DR STRING; 44689.DDB0252580; -.
DR PaxDb; Q86KC1; -.
DR EnsemblProtists; EAL69983; EAL69983; DDB_G0274181.
DR GeneID; 8619712; -.
DR KEGG; ddi:DDB_G0274181; -.
DR dictyBase; DDB_G0274181; lyEh1.
DR eggNOG; ENOG502S1SN; Eukaryota.
DR HOGENOM; CLU_073372_3_0_1; -.
DR InParanoid; Q86KC1; -.
DR OMA; NGHQDYT; -.
DR PhylomeDB; Q86KC1; -.
DR PRO; PR:Q86KC1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0003796; F:lysozyme activity; IEA:UniProtKB-EC.
DR GO; GO:0016998; P:cell wall macromolecule catabolic process; IEA:InterPro.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR002053; Glyco_hydro_25.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR Pfam; PF01183; Glyco_hydro_25; 1.
DR SUPFAM; SSF51445; SSF51445; 1.
DR PROSITE; PS51904; GLYCOSYL_HYDROL_F25_2; 1.
PE 3: Inferred from homology;
KW Antimicrobial; Bacteriolytic enzyme; Glycosidase; Hydrolase;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..212
FT /note="Probable GH family 25 lysozyme 2"
FT /id="PRO_0000330648"
FT DOMAIN 20..212
FT /note="Ch-type lysozyme"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"
FT ACT_SITE 24
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"
FT ACT_SITE 112
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"
FT ACT_SITE 114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"
SQ SEQUENCE 212 AA; 23202 MW; B6036D806E5E8281 CRC64;
MRFIALLISF FALLKVISAI SGVDISSAST IESFTCLKSA GYDFAIIRAY ESLGQVDPNG
PHSVYNARDA GIEYVDVYMF PCPTCGNGAG QAETMVNYLK GYNANYGMVW LDIEGPQYWM
SQSENVAFFE SLVAGLKAEG AHIGVYTSAS QWEPIMGGYT GGSEFPLWYA HYDGNPSFSD
FSPFNGWSTP SVKQYDDTGD SCGLGFDLNW YP
