LYSG3_DICDI
ID LYSG3_DICDI Reviewed; 480 AA.
AC Q8T2I5; Q551J0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Probable GH family 25 lysozyme 3;
DE EC=3.2.1.17;
DE AltName: Full=1,4-beta-N-acetylmuramidase 3;
DE Flags: Precursor;
GN ORFNames=DDB_G0276439;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC between N-acetyl-D-glucosamine residues in chitodextrins.;
CC EC=3.2.1.17;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 25 family.
CC {ECO:0000255|PROSITE-ProRule:PRU01252, ECO:0000305}.
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DR EMBL; AAFI02000015; EAL69173.1; -; Genomic_DNA.
DR RefSeq; XP_643144.1; XM_638052.1.
DR AlphaFoldDB; Q8T2I5; -.
DR SMR; Q8T2I5; -.
DR PaxDb; Q8T2I5; -.
DR EnsemblProtists; EAL69173; EAL69173; DDB_G0276439.
DR GeneID; 8620551; -.
DR KEGG; ddi:DDB_G0276439; -.
DR dictyBase; DDB_G0276439; lyEh4.
DR eggNOG; ENOG502SF04; Eukaryota.
DR HOGENOM; CLU_569163_0_0_1; -.
DR OMA; CTQSIVN; -.
DR PRO; PR:Q8T2I5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0003796; F:lysozyme activity; IEA:UniProtKB-EC.
DR GO; GO:0016998; P:cell wall macromolecule catabolic process; IEA:InterPro.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR002053; Glyco_hydro_25.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR Pfam; PF01183; Glyco_hydro_25; 1.
DR SUPFAM; SSF51445; SSF51445; 1.
DR PROSITE; PS51904; GLYCOSYL_HYDROL_F25_2; 1.
PE 3: Inferred from homology;
KW Antimicrobial; Bacteriolytic enzyme; Glycoprotein; Glycosidase; Hydrolase;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..480
FT /note="Probable GH family 25 lysozyme 3"
FT /id="PRO_0000330649"
FT DOMAIN 21..231
FT /note="Ch-type lysozyme"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"
FT REGION 219..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 25
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"
FT ACT_SITE 114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"
FT ACT_SITE 116
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01252"
FT CARBOHYD 423
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 428
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 437
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 446
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 468
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 480 AA; 46450 MW; DE6A8A54794891E3 CRC64;
MNKLILSILS VLLIVSIASA GNGIDISSGT NPSSSDLACL AKQNSKIIVQ TWSGGYGFNS
NVPSIVQAAK SAGLSVDLYA FLCSQCSGIT DPAEAIKTLV SKLNGVKYGT LWIDVEQCNG
CWSSTLSSNA QYVQTAVQTA SQLGVNVGVY SSEGEWPQTV GSLTSLSSFP LWYAHYDNNP
SFSDQGYNFG GWSKAVMKQY QGTTTQCGVS VDLNWFPGSG SSTTSSSATS SSTTGRPLTS
SSGAGTGGHS SSSGAGTGGH SSTTGGQTSG QTSGQTSGSS NQPLSSGSSQ DSSNSGSSNQ
PLSSGSSQDS SNSGSSNQPL SSGSSQTSGQ TSGSSNQPLS SGSSQDSGSN SGSQGTTGSQ
SGSSSSNPLT SGSQSGSSGS QSTSSGSQSG SSGATGTSST ASSTSATGSS STGSSTGSSS
GSNDSGSNDS GSSSGSNNSG SSSGSNNSGS SSGSASSSGS SGSSGSGNYT SGSGNGAFLF
