ID   LYSG_COREF              Reviewed;         290 AA.
AC   Q8RQM5;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Lysine export transcriptional regulatory protein LysG {ECO:0000250|UniProtKB:P94632};
GN   Name=lysG; OrderedLocusNames=CE1358;
OS   Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS   / NBRC 100395).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RA   Itaya H., Kimura E., Kawahara Y., Sugimoto S.;
RT   "lysG, lysE of Corynebacterium efficiens.";
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA   Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- FUNCTION: Positively regulates the expression of the exporter LysE.
CC       {ECO:0000250|UniProtKB:P94632}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AB083133; BAB88826.1; -; Genomic_DNA.
DR   EMBL; BA000035; BAC18168.1; -; Genomic_DNA.
DR   RefSeq; WP_006769322.1; NZ_GG700686.1.
DR   AlphaFoldDB; Q8RQM5; -.
DR   SMR; Q8RQM5; -.
DR   STRING; 196164.23493197; -.
DR   EnsemblBacteria; BAC18168; BAC18168; BAC18168.
DR   KEGG; cef:CE1358; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_063829_0_1_11; -.
DR   OMA; QQWKLDS; -.
DR   OrthoDB; 951478at2; -.
DR   Proteomes; UP000001409; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR017685; ArgP.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR03298; argP; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..290
FT                   /note="Lysine export transcriptional regulatory protein
FT                   LysG"
FT                   /id="PRO_0000105667"
FT   DOMAIN          1..57
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   290 AA;  31564 MW;  B8CB9D952B4DB72C CRC64;
     MNPIHLDTLL TIIDEGSFEN ASLALSISPS AVSQRIKALE KSVGRVLVSR TQPAVATEAG
     EVLVQAARKM ALLQAETREQ LAERLDEIPL TVAINADSLS TWFPPVFAEV AHWGAVTLTL
     RVEDEAHTLS LLRRGSVLGA VTREADPVAG CEVLRLGVMR HLPVATPELR ARYTVDGQPD
     WVRMPVLRFG PNDVLQDRDL EGRVDGAVAR RRVSVVPSAE GFGEAVRLGL GWGLLPEAQA
     APMLAAGDVV QLDEKVVDTP LYWQRWRLES RLLARLTDAV VDAARAGLRT