ID   LYSG_MYCBO              Reviewed;         303 AA.
AC   P67666; A0A1R3XZU7; Q10872; X2BJS2;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=HTH-type transcriptional regulator LysG {ECO:0000250|UniProtKB:P9WMF5};
GN   Name=lysG {ECO:0000250|UniProtKB:P9WMF5}; OrderedLocusNames=BQ2027_MB2007C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Positively regulates the expression of the exporter LysE and
CC       represses its own expression. {ECO:0000250|UniProtKB:P9WMF5}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P9WMF5}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIU00613.1; -; Genomic_DNA.
DR   RefSeq; NP_855657.1; NC_002945.3.
DR   RefSeq; WP_003409986.1; NC_002945.4.
DR   AlphaFoldDB; P67666; -.
DR   SMR; P67666; -.
DR   EnsemblBacteria; SIU00613; SIU00613; BQ2027_MB2007C.
DR   GeneID; 45425964; -.
DR   PATRIC; fig|233413.5.peg.2205; -.
DR   OMA; QQWKLDS; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR017685; ArgP.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR03298; argP; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..303
FT                   /note="HTH-type transcriptional regulator LysG"
FT                   /id="PRO_0000105813"
FT   DOMAIN          6..62
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   303 AA;  32837 MW;  344BDB1056207144 CRC64;
     MVDPQLDGPQ LAALAAVVEL GSFDAAAERL HVTPSAVSQR IKSLEQQVGQ VLVVREKPCR
     ATTAGIPLLR LAAQTALLES EALAEMGGNA SLKRTRITIA VNADSMATWF SAVFDGLGDV
     LLDVRIEDQD HSARLLREGV AMGAVTTERN PVPGCRVHPL GEMRYLPVAS RPFVQRHLSD
     GFTAAAAAKA PSLAWNRDDG LQDMLVRKAF RRAITRPTHF VPTTEGFTAA ARAGLGWGMF
     PEKLAASPLA DGSFVRVCDI HLDVPLYWQC WKLDSPIIAR ITDTVRAAAS GLYRGQQRRR
     RPG