ID   LYSG_MYCTO              Reviewed;         303 AA.
AC   P9WMF4; L0TB04; P67665; Q10872;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=HTH-type transcriptional regulator LysG {ECO:0000250|UniProtKB:P9WMF5};
GN   Name=lysG {ECO:0000250|UniProtKB:P9WMF5}; OrderedLocusNames=MT2039;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Positively regulates the expression of the exporter LysE and
CC       represses its own expression. {ECO:0000250|UniProtKB:P9WMF5}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P9WMF5}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK46314.1; -; Genomic_DNA.
DR   PIR; G70756; G70756.
DR   RefSeq; WP_003409986.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMF4; -.
DR   SMR; P9WMF4; -.
DR   EnsemblBacteria; AAK46314; AAK46314; MT2039.
DR   GeneID; 45425964; -.
DR   KEGG; mtc:MT2039; -.
DR   PATRIC; fig|83331.31.peg.2195; -.
DR   HOGENOM; CLU_063829_0_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR017685; ArgP.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR03298; argP; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..303
FT                   /note="HTH-type transcriptional regulator LysG"
FT                   /id="PRO_0000427313"
FT   DOMAIN          6..62
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   303 AA;  32837 MW;  344BDB1056207144 CRC64;
     MVDPQLDGPQ LAALAAVVEL GSFDAAAERL HVTPSAVSQR IKSLEQQVGQ VLVVREKPCR
     ATTAGIPLLR LAAQTALLES EALAEMGGNA SLKRTRITIA VNADSMATWF SAVFDGLGDV
     LLDVRIEDQD HSARLLREGV AMGAVTTERN PVPGCRVHPL GEMRYLPVAS RPFVQRHLSD
     GFTAAAAAKA PSLAWNRDDG LQDMLVRKAF RRAITRPTHF VPTTEGFTAA ARAGLGWGMF
     PEKLAASPLA DGSFVRVCDI HLDVPLYWQC WKLDSPIIAR ITDTVRAAAS GLYRGQQRRR
     RPG