LYSI_CORGL
ID LYSI_CORGL Reviewed; 501 AA.
AC P35865;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=L-lysine transport protein;
DE AltName: Full=L-lysine permease;
GN Name=lysI; OrderedLocusNames=Cgl0968, cg1105;
OS Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS JCM 1318 / LMG 3730 / NCIMB 10025).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=196627;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=1667221; DOI=10.1111/j.1365-2958.1991.tb01859.x;
RA Seep-Feldhaus A.H., Kalinowski J., Puehler A.;
RT "Molecular analysis of the Corynebacterium glutamicum lysl gene involved in
RT lysine uptake.";
RL Mol. Microbiol. 5:2995-3005(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA Ikeda M., Nakagawa S.;
RT "The Corynebacterium glutamicum genome: features and impacts on
RT biotechnological processes.";
RL Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=12948626; DOI=10.1016/s0168-1656(03)00154-8;
RA Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A.,
RA Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A.,
RA Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F.,
RA Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O.,
RA Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
RT "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its
RT impact on the production of L-aspartate-derived amino acids and vitamins.";
RL J. Biotechnol. 104:5-25(2003).
CC -!- FUNCTION: Permease that is involved in the transport across the
CC membrane of lysine.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC family. {ECO:0000305}.
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DR EMBL; X60312; CAA42855.1; -; Genomic_DNA.
DR EMBL; BA000036; BAB98361.1; -; Genomic_DNA.
DR EMBL; BX927150; CAF19675.1; -; Genomic_DNA.
DR PIR; S18573; S18573.
DR RefSeq; NP_600195.1; NC_003450.3.
DR RefSeq; WP_011014015.1; NC_006958.1.
DR AlphaFoldDB; P35865; -.
DR SMR; P35865; -.
DR STRING; 196627.cg1105; -.
DR TCDB; 2.A.3.2.4; the amino acid-polyamine-organocation (apc) family.
DR KEGG; cgb:cg1105; -.
DR KEGG; cgl:Cgl0968; -.
DR PATRIC; fig|196627.13.peg.953; -.
DR eggNOG; COG0531; Bacteria.
DR HOGENOM; CLU_007946_1_2_11; -.
DR OMA; THDFWGE; -.
DR Proteomes; UP000000582; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004754; Amino_acid_antiprt.
DR Pfam; PF13520; AA_permease_2; 1.
DR TIGRFAMs; TIGR00905; 2A0302; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..501
FT /note="L-lysine transport protein"
FT /id="PRO_0000054249"
FT TRANSMEM 25..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..495
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 501 AA; 53630 MW; 055303EB8A094775 CRC64;
MNTQSDSAGS QGAAATSRTV SIRTLIALII GSTVGAGIFS IPQNIGSVAG PGAMLIGWLI
AGVGMLSVAF VFHVLARRKP HLDSGVYAYA RVGLGDYVGF SSAWGYWLGS VIAQVGYATL
FFSTLGHYVP LFSQDHPFVS ALAVSALTWL VFGVVSRGIS QAAFLTTVTT VAKILPLLCF
IILVAFLGFS WEKFTVDLWA RDGGVGSIFD QVRGIMVYTV WVFIGIEGAS VYSRQARSRS
DVSRATVIGF VAVLLLLVSI SSLSFGVLTQ QELAALPDNS MASVLEAVVG PWGAALISLG
LCLSVLGAYV SWQMLCAEPL ALMAMDGLIP SKIGAINSRG AAWMAQLIST IVIQIFIIIF
FLNETTYVSM VQLATNLYLV PYLFSAFYLV MLATRGKGIT HPHAGTRFDD SGPEISRREN
RKHLIVGLVA TVYSVWLFYA AEPQFVLFGA MAMLPGLIPY VWTRIYRGEQ VFNRFEIGVV
VVLVVAASAG VIGLVNGSLS L
