LYSM3_HUMAN
ID LYSM3_HUMAN Reviewed; 306 AA.
AC Q7Z3D4; Q5H9U0; Q6PEK0; Q9NTE9;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=LysM and putative peptidoglycan-binding domain-containing protein 3;
GN Name=LYSMD3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Mammary cancer, Retina, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=29851555; DOI=10.1091/mbc.e17-11-0693;
RA Serebrenik Y.V., Hellerschmied D., Toure M., Lopez-Giraldez F.,
RA Brookner D., Crews C.M.;
RT "Targeted protein unfolding uncovers a Golgi-specific transcriptional
RT stress response.";
RL Mol. Biol. Cell 29:1284-1298(2018).
CC -!- FUNCTION: Essential for Golgi structural integrity.
CC {ECO:0000269|PubMed:29851555}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29851555};
CC Single-pass membrane protein {ECO:0000255}. Golgi apparatus
CC {ECO:0000269|PubMed:29851555}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7Z3D4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z3D4-2; Sequence=VSP_020126, VSP_020127;
CC Name=3;
CC IsoId=Q7Z3D4-3; Sequence=VSP_020125, VSP_020128;
CC -!- INDUCTION: Up-regulated by Golgi stress-inducing agent nigericin.
CC {ECO:0000269|PubMed:29851555}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD97936.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL137315; CAB70692.1; -; mRNA.
DR EMBL; BX537972; CAD97936.1; ALT_INIT; mRNA.
DR EMBL; CR933624; CAI45934.1; -; mRNA.
DR EMBL; BC058027; AAH58027.1; -; mRNA.
DR CCDS; CCDS43338.1; -. [Q7Z3D4-1]
DR CCDS; CCDS68911.1; -. [Q7Z3D4-2]
DR PIR; T46287; T46287.
DR RefSeq; NP_001273741.1; NM_001286812.1. [Q7Z3D4-2]
DR RefSeq; NP_938014.1; NM_198273.2. [Q7Z3D4-1]
DR RefSeq; XP_005248478.1; XM_005248421.4. [Q7Z3D4-1]
DR AlphaFoldDB; Q7Z3D4; -.
DR BioGRID; 125469; 17.
DR IntAct; Q7Z3D4; 2.
DR STRING; 9606.ENSP00000314518; -.
DR GlyGen; Q7Z3D4; 2 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q7Z3D4; -.
DR PhosphoSitePlus; Q7Z3D4; -.
DR BioMuta; LYSMD3; -.
DR DMDM; 114150022; -.
DR EPD; Q7Z3D4; -.
DR jPOST; Q7Z3D4; -.
DR MassIVE; Q7Z3D4; -.
DR MaxQB; Q7Z3D4; -.
DR PaxDb; Q7Z3D4; -.
DR PeptideAtlas; Q7Z3D4; -.
DR PRIDE; Q7Z3D4; -.
DR ProteomicsDB; 69029; -. [Q7Z3D4-1]
DR ProteomicsDB; 69030; -. [Q7Z3D4-2]
DR ProteomicsDB; 69031; -. [Q7Z3D4-3]
DR Antibodypedia; 2640; 56 antibodies from 16 providers.
DR DNASU; 116068; -.
DR Ensembl; ENST00000315948.11; ENSP00000314518.6; ENSG00000176018.13. [Q7Z3D4-1]
DR Ensembl; ENST00000500869.6; ENSP00000427020.1; ENSG00000176018.13. [Q7Z3D4-3]
DR Ensembl; ENST00000509384.5; ENSP00000427683.1; ENSG00000176018.13. [Q7Z3D4-2]
DR GeneID; 116068; -.
DR KEGG; hsa:116068; -.
DR MANE-Select; ENST00000315948.11; ENSP00000314518.6; NM_198273.2; NP_938014.1.
DR UCSC; uc003kjr.5; human. [Q7Z3D4-1]
DR CTD; 116068; -.
DR DisGeNET; 116068; -.
DR GeneCards; LYSMD3; -.
DR HGNC; HGNC:26969; LYSMD3.
DR HPA; ENSG00000176018; Low tissue specificity.
DR neXtProt; NX_Q7Z3D4; -.
DR OpenTargets; ENSG00000176018; -.
DR PharmGKB; PA142671495; -.
DR VEuPathDB; HostDB:ENSG00000176018; -.
DR eggNOG; KOG2850; Eukaryota.
DR GeneTree; ENSGT00940000158711; -.
DR HOGENOM; CLU_1739900_0_0_1; -.
DR InParanoid; Q7Z3D4; -.
DR OMA; RRKDPYY; -.
DR PhylomeDB; Q7Z3D4; -.
DR TreeFam; TF326271; -.
DR PathwayCommons; Q7Z3D4; -.
DR SignaLink; Q7Z3D4; -.
DR BioGRID-ORCS; 116068; 14 hits in 1065 CRISPR screens.
DR GeneWiki; LYSMD3; -.
DR GenomeRNAi; 116068; -.
DR Pharos; Q7Z3D4; Tdark.
DR PRO; PR:Q7Z3D4; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q7Z3D4; protein.
DR Bgee; ENSG00000176018; Expressed in parietal pleura and 176 other tissues.
DR ExpressionAtlas; Q7Z3D4; baseline and differential.
DR Genevisible; Q7Z3D4; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0007030; P:Golgi organization; IMP:UniProtKB.
DR CDD; cd00118; LysM; 1.
DR Gene3D; 3.10.350.10; -; 1.
DR InterPro; IPR045030; LYSM1-4.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR PANTHER; PTHR20932; PTHR20932; 1.
DR Pfam; PF01476; LysM; 1.
DR SMART; SM00257; LysM; 1.
DR SUPFAM; SSF54106; SSF54106; 1.
DR PROSITE; PS51782; LYSM; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Glycoprotein; Golgi apparatus;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..306
FT /note="LysM and putative peptidoglycan-binding domain-
FT containing protein 3"
FT /id="PRO_0000248007"
FT TOPO_DOM 1..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 65..109
FT /note="LysM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT MOD_RES 55
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 86..150
FT /note="VADIKRVNNLISDQDFFALRSIKIPVKKFSSLTETLCPPKGRQTSRHSSVQY
FT SSEQQEILPANDS -> LRWMLVIIQQWTLHIYIQKSHPHHSREKWKMELCQLKEYISA
FT NKMIINCIVKILSHLLLNRKHSN (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_020125"
FT VAR_SEQ 87..127
FT /note="ADIKRVNNLISDQDFFALRSIKIPVKKFSSLTETLCPPKGR -> YQNSSKK
FT VQFLDRNTLSSKRKTDFTSFICSILFRTTGNFAS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020126"
FT VAR_SEQ 128..306
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020127"
FT VAR_SEQ 151..306
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_020128"
SQ SEQUENCE 306 AA; 34538 MW; DBCEAF17C2ADC42D CRC64;
MAGRHQNRSF PLPGVQSSGQ VHAFGNCSDS DILEEDAEVY ELRSRGKEKV RRSTSRDRLD
DIIVLTKDIQ EGDTLNAIAL QYCCTVADIK RVNNLISDQD FFALRSIKIP VKKFSSLTET
LCPPKGRQTS RHSSVQYSSE QQEILPANDS LAYSDSAGSF LKEVDRDIEQ IVKCTDNKRE
NLNEVVSALT AQQMRFEPDN KNTQRKDPYY GADWGIGWWT AVVIMLIVGI ITPVFYLLYY
EILAKVDVSH HSTVDSSHLH SKITPPSQQR EMENGIVPTK GIHFSQQDDH KLYSQDSQSP
AAQQET
