ID   LYSM3_MOUSE             Reviewed;         305 AA.
AC   Q99LE3;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=LysM and putative peptidoglycan-binding domain-containing protein 3;
GN   Name=Lysmd3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Essential for Golgi structural integrity.
CC       {ECO:0000250|UniProtKB:Q7Z3D4}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7Z3D4};
CC       Single-pass membrane protein {ECO:0000255}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q7Z3D4}.
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DR   EMBL; BC003322; AAH03322.1; -; mRNA.
DR   CCDS; CCDS26660.1; -.
DR   RefSeq; NP_084533.1; NM_030257.1.
DR   RefSeq; XP_006517538.1; XM_006517475.2.
DR   AlphaFoldDB; Q99LE3; -.
DR   STRING; 10090.ENSMUSP00000038275; -.
DR   GlyGen; Q99LE3; 3 sites.
DR   iPTMnet; Q99LE3; -.
DR   PhosphoSitePlus; Q99LE3; -.
DR   EPD; Q99LE3; -.
DR   MaxQB; Q99LE3; -.
DR   PaxDb; Q99LE3; -.
DR   PeptideAtlas; Q99LE3; -.
DR   PRIDE; Q99LE3; -.
DR   ProteomicsDB; 292155; -.
DR   Antibodypedia; 2640; 56 antibodies from 16 providers.
DR   DNASU; 80289; -.
DR   Ensembl; ENSMUST00000224300; ENSMUSP00000152940; ENSMUSG00000035840.
DR   GeneID; 80289; -.
DR   KEGG; mmu:80289; -.
DR   UCSC; uc007rhw.1; mouse.
DR   CTD; 116068; -.
DR   MGI; MGI:1915906; Lysmd3.
DR   VEuPathDB; HostDB:ENSMUSG00000035840; -.
DR   eggNOG; KOG2850; Eukaryota.
DR   GeneTree; ENSGT00940000158711; -.
DR   HOGENOM; CLU_070676_0_0_1; -.
DR   InParanoid; Q99LE3; -.
DR   OMA; RRKDPYY; -.
DR   OrthoDB; 1180847at2759; -.
DR   PhylomeDB; Q99LE3; -.
DR   TreeFam; TF326271; -.
DR   BioGRID-ORCS; 80289; 2 hits in 74 CRISPR screens.
DR   ChiTaRS; Lysmd3; mouse.
DR   PRO; PR:Q99LE3; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q99LE3; protein.
DR   Bgee; ENSMUSG00000035840; Expressed in humerus cartilage element and 247 other tissues.
DR   ExpressionAtlas; Q99LE3; baseline and differential.
DR   Genevisible; Q99LE3; MM.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR   CDD; cd00118; LysM; 1.
DR   Gene3D; 3.10.350.10; -; 1.
DR   InterPro; IPR045030; LYSM1-4.
DR   InterPro; IPR018392; LysM_dom.
DR   InterPro; IPR036779; LysM_dom_sf.
DR   PANTHER; PTHR20932; PTHR20932; 1.
DR   Pfam; PF01476; LysM; 1.
DR   SMART; SM00257; LysM; 1.
DR   PROSITE; PS51782; LYSM; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..305
FT                   /note="LysM and putative peptidoglycan-binding domain-
FT                   containing protein 3"
FT                   /id="PRO_0000248008"
FT   TOPO_DOM        1..216
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        238..305
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          65..109
FT                   /note="LysM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT   REGION          253..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..305
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         55
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z3D4"
FT   CARBOHYD        7
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        199
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   305 AA;  34258 MW;  CC65D0C53B734462 CRC64;
     MAGRNQNRTV SLPGIQASGH VLAFGNCTDN DMLEEDAEVY ELRSRGKEKV RRSASRDRLD
     DIVILTKDIQ EGDTLNAVAL QYCCTVADIK RVNNLISDQD FFALRSIKIP VKRFSSLTET
     LHPLKGRHIL HPPPVPYFQE QDIVPADGSL SSSESAGSFL KEVDRDIEQI VKCTDTKKEN
     LNEVVSALTA QQVRFEPDNK SIHRKDPYYG ADWGIGWWTA VVIMLIVGII TPVFYLLYYE
     ILAKVDVSHH STVGSSHLHP GLTPPTQHRE MENEIGPTKG IPVGQQDDHK LYRQDPQAHD
     AQHKT