LYSM4_DANRE
ID LYSM4_DANRE Reviewed; 267 AA.
AC Q6P606; A5WV08; A8E7R1;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=LysM and putative peptidoglycan-binding domain-containing protein 4;
GN Name=lysmd4; ORFNames=si:dkey-111m11.2, si:dkeyp-82d11.1, zgc:77861;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; BX649426; CAP09282.1; -; Genomic_DNA.
DR EMBL; CR925803; CAN88102.2; -; Genomic_DNA.
DR EMBL; CU570785; CAN88102.2; JOINED; Genomic_DNA.
DR EMBL; CU570785; CAX12642.1; -; Genomic_DNA.
DR EMBL; CR925803; CAX12642.1; JOINED; Genomic_DNA.
DR EMBL; BC062528; AAH62528.1; -; mRNA.
DR RefSeq; NP_957144.2; NM_200850.2.
DR AlphaFoldDB; Q6P606; -.
DR SMR; Q6P606; -.
DR STRING; 7955.ENSDARP00000090237; -.
DR PaxDb; Q6P606; -.
DR Ensembl; ENSDART00000099463; ENSDARP00000090237; ENSDARG00000068702.
DR GeneID; 100149102; -.
DR KEGG; dre:100149102; -.
DR CTD; 145748; -.
DR ZFIN; ZDB-GENE-040426-1895; lysmd4.
DR eggNOG; KOG2850; Eukaryota.
DR GeneTree; ENSGT00940000160583; -.
DR HOGENOM; CLU_070676_1_0_1; -.
DR InParanoid; Q6P606; -.
DR OMA; MWRGENG; -.
DR OrthoDB; 1180847at2759; -.
DR PhylomeDB; Q6P606; -.
DR TreeFam; TF326271; -.
DR PRO; PR:Q6P606; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000068702; Expressed in muscle tissue and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00118; LysM; 1.
DR Gene3D; 3.10.350.10; -; 1.
DR InterPro; IPR045030; LYSM1-4.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR PANTHER; PTHR20932; PTHR20932; 1.
DR PROSITE; PS51782; LYSM; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..267
FT /note="LysM and putative peptidoglycan-binding domain-
FT containing protein 4"
FT /id="PRO_0000248016"
FT TOPO_DOM 1..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..267
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 70..114
FT /note="LysM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT REGION 30..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 7
FT /note="P -> L (in Ref. 1; CAP09282 and 2; AAH62528)"
FT /evidence="ECO:0000305"
FT CONFLICT 146
FT /note="A -> T (in Ref. 2; AAH62528)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="V -> L (in Ref. 2; AAH62528)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 267 AA; 30171 MW; 3D11A7C294E9639A CRC64;
MRRGDPPPRA FQAPVDVHAS ADGQVYMFRH RQEEPEASSE DEELNVMELR PRSRDSSSKE
KEGVGEMLLL ERDISHEDNL SKLALQYGCK VADIKRVNNL FQEQDMYALK SIKIPVRKHG
LLTEAISELR TPQQRPSHDA APSNSAMASV SGRPQVQEYT NYLKEVDNDI ERLIQNTDNV
EEVFSASSRV SRGWGWRSQR LRSNGADWGI QWWNAVIAML LIGIVLPIFY VVYYKTKDSG
ESAVDNVGVN ISVSTSNSTR EYNGKSP
