LYSM4_MOUSE
ID LYSM4_MOUSE Reviewed; 293 AA.
AC Q8CC84; Q6PFQ8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=LysM and putative peptidoglycan-binding domain-containing protein 4;
GN Name=Lysmd4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cecum, Oviduct, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CC84-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CC84-2; Sequence=VSP_020129;
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DR EMBL; AK033681; BAC28427.1; -; mRNA.
DR EMBL; AK143241; BAE25322.1; -; mRNA.
DR EMBL; AK172203; BAE42879.1; -; mRNA.
DR EMBL; BC057459; AAH57459.1; -; mRNA.
DR CCDS; CCDS21350.1; -. [Q8CC84-1]
DR RefSeq; NP_001177980.1; NM_001191051.1. [Q8CC84-1]
DR RefSeq; NP_780424.1; NM_175215.4. [Q8CC84-1]
DR RefSeq; XP_006541300.1; XM_006541237.2.
DR AlphaFoldDB; Q8CC84; -.
DR SMR; Q8CC84; -.
DR GlyGen; Q8CC84; 1 site.
DR iPTMnet; Q8CC84; -.
DR PhosphoSitePlus; Q8CC84; -.
DR EPD; Q8CC84; -.
DR MaxQB; Q8CC84; -.
DR PaxDb; Q8CC84; -.
DR PRIDE; Q8CC84; -.
DR ProteomicsDB; 252694; -. [Q8CC84-1]
DR Antibodypedia; 29207; 99 antibodies from 16 providers.
DR DNASU; 75099; -.
DR Ensembl; ENSMUST00000058771; ENSMUSP00000053341; ENSMUSG00000043831. [Q8CC84-1]
DR Ensembl; ENSMUST00000208998; ENSMUSP00000146557; ENSMUSG00000043831. [Q8CC84-1]
DR GeneID; 75099; -.
DR KEGG; mmu:75099; -.
DR UCSC; uc009hia.2; mouse. [Q8CC84-1]
DR CTD; 145748; -.
DR MGI; MGI:1922349; Lysmd4.
DR VEuPathDB; HostDB:ENSMUSG00000043831; -.
DR eggNOG; KOG2850; Eukaryota.
DR GeneTree; ENSGT00940000160583; -.
DR HOGENOM; CLU_070676_1_0_1; -.
DR InParanoid; Q8CC84; -.
DR OMA; MWRGENG; -.
DR OrthoDB; 1180847at2759; -.
DR PhylomeDB; Q8CC84; -.
DR TreeFam; TF326271; -.
DR BioGRID-ORCS; 75099; 2 hits in 74 CRISPR screens.
DR PRO; PR:Q8CC84; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8CC84; protein.
DR Bgee; ENSMUSG00000043831; Expressed in facial nucleus and 226 other tissues.
DR ExpressionAtlas; Q8CC84; baseline and differential.
DR Genevisible; Q8CC84; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00118; LysM; 1.
DR Gene3D; 3.10.350.10; -; 1.
DR InterPro; IPR045030; LYSM1-4.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR PANTHER; PTHR20932; PTHR20932; 1.
DR SMART; SM00257; LysM; 1.
DR PROSITE; PS51782; LYSM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..293
FT /note="LysM and putative peptidoglycan-binding domain-
FT containing protein 4"
FT /id="PRO_0000248014"
FT TOPO_DOM 1..214
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 71..115
FT /note="LysM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT REGION 28..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..130
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_020129"
SQ SEQUENCE 293 AA; 31660 MW; 963E6147C136C309 CRC64;
MRQKEVLAKS FQGPAAVCRT PNSHVYMFNN GSGDSGDSSE EESHQVVLRP RGKEHQKNSS
QRPGAGTMVL LQRELAQEDS LNKLALQYGC KVADIKKANN FIREQDLYAL KSIKIPVRNH
GILTETHQEL MPLGASSSET RVTLVDLPED EDAGGATTQG NQLTDFFKGI DENIERAVHS
DVFHGDSCCV EAPDQLLLPI TQKPVADGAD CGIQWWNAVF LMLLIGIVLP VFYLVYFKIQ
ATGEPSNGLN ATVVPNGSMT LSPVPGQAPR LAIPVPTLPA SDSQVSPTTQ AGA
