ID   LYSRL_PSEAB             Reviewed;         317 AA.
AC   A0A0H2ZDG9;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2017, sequence version 2.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=HTH-type transcriptional repressor PA14_22550 {ECO:0000305|PubMed:24550745};
GN   OrderedLocusNames=PA14_22550 {ECO:0000312|EMBL:ABJ12449.1};
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G.,
RA   Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=UCBPP-PA14;
RX   PubMed=24550745; DOI=10.1371/journal.pgen.1004163;
RA   Moyano A.J., Tobares R.A., Rizzi Y.S., Krapp A.R., Mondotte J.A.,
RA   Bocco J.L., Saleh M.C., Carrillo N., Smania A.M.;
RT   "A long-chain flavodoxin protects Pseudomonas aeruginosa from oxidative
RT   stress and host bacterial clearance.";
RL   PLoS Genet. 10:E1004163-E1004163(2014).
CC   -!- FUNCTION: Represses the transcription of the operon that consists of
CC       PA14_22510 to PA14_22540. {ECO:0000269|PubMed:24550745}.
CC   -!- DISRUPTION PHENOTYPE: Inactivation of this gene produces a 3.4-fold
CC       increase in the expression of fldP in cells untreated by H(2)O(2).
CC       {ECO:0000269|PubMed:24550745}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABJ12449.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP000438; ABJ12449.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_016254253.1; NZ_CP034244.1.
DR   AlphaFoldDB; A0A0H2ZDG9; -.
DR   SMR; A0A0H2ZDG9; -.
DR   EnsemblBacteria; ABJ12449; ABJ12449; PA14_22550.
DR   KEGG; pau:PA14_22550; -.
DR   HOGENOM; CLU_039613_16_3_6; -.
DR   BioCyc; PAER208963:G1G74-1878-MON; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..317
FT                   /note="HTH-type transcriptional repressor PA14_22550"
FT                   /id="PRO_0000442135"
FT   DOMAIN          1..59
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   317 AA;  34879 MW;  8538343B1F6E61BD CRC64;
     MDKLTAMATF VKVVDAGSFT RAADALGLPK ARVSQRVSDL EKHLGVRLLN RTTRALSLTH
     DGSAYFDKCQ VLLQQIDELE ATLRGGTATP IGRLRVDSLI TIARWVIAPR LHDFQARYPR
     IQLRLSSSDR ISNLLEDGID CTIRGGALKD SSMIARHLCD IQMGLYASPE YLASIGGVDS
     PNDLSQFRRL SWFSGRERNP FMWELESGPE RFVVQSGDGM QFDEPDVAIS ACMAGSGICP
     GAPFAVAGFV RAGKLVPVLP QWHFSAAPVH VIYPGSRHLS VRVRCFVNWV MELFAENPEI
     QLTPIALALE SGLAQRT