ID   LYS_BPFR                Reviewed;          71 AA.
AC   P19903;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Lysis protein;
OS   Enterobacteria phage fr (Bacteriophage fr).
OC   Viruses; Riboviria; Orthornavirae; Lenarviricota; Leviviricetes;
OC   Levivirales; Leviviridae; Levivirus.
OX   NCBI_TaxID=12017;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2207135; DOI=10.1016/0167-4781(90)90149-v;
RA   Adhin M.R., Avots A.J., Berzin V.M., Overbeek G.P., van Duin J.;
RT   "Complete nucleotide sequence of the group I RNA bacteriophage fr.";
RL   Biochim. Biophys. Acta 1050:104-109(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 7-35.
RA   Berzin B.M., Gribanov B.A., Tsielens I.A., Yansone H.B., Gren A.Y.;
RT   "Structure of regulator part of phage fr replicase gene.";
RL   Bioorg. Khim. 7:306-307(1981).
CC   -!- FUNCTION: Induces the formation of specific membrane adhesion sites
CC       between the inner and outer membranes, apparently leading to host cell
CC       lysis. Lysis may be performed via activation of host murein hydrolases.
CC       {ECO:0000250|UniProtKB:P03609}.
CC   -!- SUBCELLULAR LOCATION: Host cell inner membrane
CC       {ECO:0000250|UniProtKB:P03609}; Single-pass membrane protein
CC       {ECO:0000255}. Host cell outer membrane {ECO:0000250|UniProtKB:P03609};
CC       Single-pass membrane protein {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X15031; CAA33137.1; -; mRNA.
DR   PIR; S08019; S08019.
DR   SMR; P19903; -.
DR   Proteomes; UP000002582; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR022599; Phage_MS2_lysis.
DR   Pfam; PF11125; DUF2830; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Host cell inner membrane; Host cell lysis by virus;
KW   Host cell membrane; Host cell outer membrane; Host membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix;
KW   Viral release from host cell.
FT   CHAIN           1..71
FT                   /note="Lysis protein"
FT                   /id="PRO_0000164861"
FT   TRANSMEM        34..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   71 AA;  8205 MW;  D21AD5C07DC9B523 CRC64;
     MQQPSQPTRE STKKPVPFQH EEYPCQNQQR SSTLYVLICL AIFLSKFTNQ LLASLLDLLI
     RIVTTLQQLL T