LYS_BPGA
ID LYS_BPGA Reviewed; 63 AA.
AC P07233;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 23-FEB-2022, entry version 47.
DE RecName: Full=Lysis protein;
OS Enterobacteria phage GA (Bacteriophage GA).
OC Viruses; Riboviria; Orthornavirae; Lenarviricota; Leviviricetes;
OC Norzivirales; Fiersviridae; Emesvirus; Emesvirus japonicum.
OX NCBI_TaxID=12018;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3711059; DOI=10.1093/oxfordjournals.jbchem.a135580;
RA Inokuchi Y., Takahashi R., Hirose T., Inayama S., Jacobson A.B.,
RA Hirashima A.;
RT "The complete nucleotide sequence of the group II RNA coliphage GA.";
RL J. Biochem. 99:1169-1180(1986).
CC -!- FUNCTION: Induces the formation of specific membrane adhesion sites
CC between the inner and outer membranes, apparently leading to host cell
CC lysis. Lysis may be performed via activation of host murein hydrolases.
CC {ECO:0000250|UniProtKB:P03609}.
CC -!- SUBCELLULAR LOCATION: Host cell inner membrane
CC {ECO:0000250|UniProtKB:P03609}; Single-pass membrane protein
CC {ECO:0000255}. Host cell outer membrane {ECO:0000250|UniProtKB:P03609};
CC Single-pass membrane protein {ECO:0000255}.
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DR EMBL; X03869; CAA27498.1; -; mRNA.
DR PIR; B29178; YVBPGA.
DR Proteomes; UP000002126; Genome.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR InterPro; IPR022599; Phage_MS2_lysis.
DR Pfam; PF11125; DUF2830; 1.
PE 3: Inferred from homology;
KW Cytolysis; Host cell inner membrane; Host cell lysis by virus;
KW Host cell membrane; Host cell outer membrane; Host membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix;
KW Viral release from host cell.
FT CHAIN 1..63
FT /note="Lysis protein"
FT /id="PRO_0000164862"
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 63 AA; 7358 MW; E7A8F3FCDB93A646 CRC64;
MGLKAKHKEN LCSDSERSKR LYVWIALAIV LSDFTSIFSH WIWGLLILYL QTLMDLPTFV
MNV