ID   LYTR_STAAS              Reviewed;         246 AA.
AC   Q6GCL1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Transcriptional regulatory protein LytR;
DE   AltName: Full=Sensory transduction protein LytR;
GN   Name=lytR; OrderedLocusNames=SAS0238;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Member of the two-component regulatory system LytR/LytS that
CC       regulates genes involved in autolysis, programmed cell death, biofilm
CC       formation and cell wall metabolism. Participates also in sensing and
CC       responding to host defense cationic antimicrobial peptides (HDPs). Upon
CC       phosphorylation by LytS, functions as a transcription regulator by
CC       direct binding to promoter regions of target genes including lrgA and
CC       lrgB, to positively regulate their expression.
CC       {ECO:0000250|UniProtKB:P60611}.
CC   -!- SUBUNIT: Homodimer; when phosphorylated.
CC       {ECO:0000250|UniProtKB:P60609}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated and dephosphorylated by LytS.
CC       {ECO:0000250|UniProtKB:P60609}.
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DR   EMBL; BX571857; CAG42008.1; -; Genomic_DNA.
DR   RefSeq; WP_000645456.1; NC_002953.3.
DR   AlphaFoldDB; Q6GCL1; -.
DR   SMR; Q6GCL1; -.
DR   KEGG; sas:SAS0238; -.
DR   HOGENOM; CLU_000445_14_1_9; -.
DR   OMA; DIHMPDF; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..246
FT                   /note="Transcriptional regulatory protein LytR"
FT                   /id="PRO_0000081130"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          141..245
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         53
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   246 AA;  28164 MW;  4DDFB5D2750185FE CRC64;
     MKALIIDDEP LARNELTYLL NEIGGFEEIN EAENVKETLE ALLINQYDII FLDVNLMDEN
     GIELGAKIQK MKEPPAIIFA TAHDQYAVQA FELNATDYIL KPFGQKRIEQ AVNKVRATKA
     KDDNSASAIA NDMSANFDQS LPVEIDDKIH MLKQQNIIGI GTHNGITTIH TTNHKYETTE
     PLNRYEKRLN PAYFIRIHRS YIINTKHIKE VQQWFNYTYM VILTNGVKMQ VGRSFMKDFK
     ASIGLL