LYTR_STAEQ
ID LYTR_STAEQ Reviewed; 252 AA.
AC Q5HLG2;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Sensory transduction protein LytR;
GN Name=lytR; OrderedLocusNames=SERP2025;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Member of the two-component regulatory system LytR/LytS that
CC probably regulates genes involved in cell wall metabolism.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated by LytS. {ECO:0000250}.
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DR EMBL; CP000029; AAW52843.1; -; Genomic_DNA.
DR RefSeq; WP_002438253.1; NC_002976.3.
DR AlphaFoldDB; Q5HLG2; -.
DR SMR; Q5HLG2; -.
DR STRING; 176279.SERP2025; -.
DR PRIDE; Q5HLG2; -.
DR EnsemblBacteria; AAW52843; AAW52843; SERP2025.
DR GeneID; 50017899; -.
DR KEGG; ser:SERP2025; -.
DR eggNOG; COG3279; Bacteria.
DR HOGENOM; CLU_000445_14_1_9; -.
DR OMA; DIHMPDF; -.
DR OrthoDB; 1958442at2; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR007492; LytTR_DNA-bd_dom.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF04397; LytTR; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00850; LytTR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50930; HTH_LYTTR; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..252
FT /note="Sensory transduction protein LytR"
FT /id="PRO_0000081134"
FT DOMAIN 2..116
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 147..251
FT /note="HTH LytTR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT MOD_RES 53
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 252 AA; 29556 MW; DEDD1AC29661FA02 CRC64;
MKALIVDDEP LARNELQYLL NLNDAIDEIE EAENIEETLE KLLYNTFDLI FLDINLMDES
GIDLAQKINK MKRSPHIIFA TAHEKFAVKA FELNATDYIL KPFEKERINQ AVNKVDMAKD
KPKNKDKTIT PKYIDYSDDE RAQTHVLPIE VDERIHILNF TDIIALSVNN GITTIDTTKQ
SYETTETLNH YEKKLPSSLF IKIHRATIVN KEHIQTIEHW FNYTYQLTLT HEFKYQVSRS
YMKTFKQQLG LQ
