ID   LYTR_STAES              Reviewed;         252 AA.
AC   Q8CN55;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Sensory transduction protein LytR;
GN   Name=lytR; OrderedLocusNames=SE_2012;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Member of the two-component regulatory system LytR/LytS that
CC       probably regulates genes involved in cell wall metabolism.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by LytS. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE015929; AAO05653.1; -; Genomic_DNA.
DR   RefSeq; NP_765567.1; NC_004461.1.
DR   RefSeq; WP_001831505.1; NZ_WBME01000003.1.
DR   AlphaFoldDB; Q8CN55; -.
DR   SMR; Q8CN55; -.
DR   STRING; 176280.SE_2012; -.
DR   EnsemblBacteria; AAO05653; AAO05653; SE_2012.
DR   KEGG; sep:SE_2012; -.
DR   PATRIC; fig|176280.10.peg.1965; -.
DR   eggNOG; COG3279; Bacteria.
DR   HOGENOM; CLU_000445_14_1_9; -.
DR   OMA; IQAFEEH; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..252
FT                   /note="Sensory transduction protein LytR"
FT                   /id="PRO_0000081133"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          147..251
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         53
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   252 AA;  29546 MW;  DD121BDD94B1FA02 CRC64;
     MKALIVDDEP LARNELQYLL NLNDAIDEIE EAENIEETLE KLLYNTFDLI FLDINLMDES
     GIDLAQKINK MKRSPHIIFA TAHEKFAVKA FELNATDYIL KPFEKERINQ AVNKVDMAKD
     KSKNKDKTIT PKYIDYSDDE RAQTHVLPIE VDERIHILNF TDIIALSVNN GITTIDTTKQ
     SYETTETLNH YEKKLPSSLF IKIHRATIVN KEHIQTIEHW FNYTYQLTLT HEFKYQVSRS
     YMKTFKQQLG LQ