ID   LYTR_STRA5              Reviewed;         246 AA.
AC   Q8E217;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Sensory transduction protein LytR;
GN   Name=lytR; OrderedLocusNames=SAG0183;
OS   Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=208435;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-611 / 2603 V/R;
RX   PubMed=12200547; DOI=10.1073/pnas.182380799;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N.,
RA   Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA   Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D.,
RA   Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A.,
RA   Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T.,
RA   Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D.,
RA   Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT   "Complete genome sequence and comparative genomic analysis of an emerging
RT   human pathogen, serotype V Streptococcus agalactiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
CC   -!- FUNCTION: Member of the two-component regulatory system LytR/LytS that
CC       probably regulates genes involved in cell wall metabolism.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by LytS. {ECO:0000250}.
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DR   EMBL; AE009948; AAM99090.1; -; Genomic_DNA.
DR   RefSeq; NP_687218.1; NC_004116.1.
DR   RefSeq; WP_000697630.1; NC_004116.1.
DR   AlphaFoldDB; Q8E217; -.
DR   SMR; Q8E217; -.
DR   STRING; 208435.SAG0183; -.
DR   EnsemblBacteria; AAM99090; AAM99090; SAG0183.
DR   KEGG; sag:SAG0183; -.
DR   PATRIC; fig|208435.3.peg.183; -.
DR   HOGENOM; CLU_000445_14_1_9; -.
DR   OMA; IQAFEEH; -.
DR   Proteomes; UP000000821; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..246
FT                   /note="Sensory transduction protein LytR"
FT                   /id="PRO_0000081136"
FT   DOMAIN          2..118
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          142..246
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         55
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   246 AA;  28145 MW;  1F21191228CE2554 CRC64;
     MKILILDDEM FARQELSFLV EHSQEVDNPE IFQAEDISEA EKILFRQQID LIFLDISLSE
     ENGFTLANQL SQLAHPPLVV FATAYDNYAV KAFESNAVDY IMKPFEQQRV DMALSKVKKL
     SQLTTASDVE QAIPKKASVE LLTLTLSDRS VVVKMQDIVA ASVEDGELTV STVQKTYTIR
     KTLNWFKSRA VAPYFLQIHR NTVINLEMIE EIQPWFNHTL LLIMSNGEKF PVGRSYLKDL
     NEHLTM