ID   LYTR_STRMU              Reviewed;         244 AA.
AC   Q8DVB7;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Sensory transduction protein LytR;
GN   Name=lytR; OrderedLocusNames=SMU_576;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Member of the two-component regulatory system LytR/LytS that
CC       probably regulates genes involved in cell wall metabolism.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by LytS. {ECO:0000250}.
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DR   EMBL; AE014133; AAN58317.1; -; Genomic_DNA.
DR   RefSeq; NP_721011.1; NC_004350.2.
DR   RefSeq; WP_002262110.1; NC_004350.2.
DR   AlphaFoldDB; Q8DVB7; -.
DR   SMR; Q8DVB7; -.
DR   STRING; 210007.SMU_576; -.
DR   PRIDE; Q8DVB7; -.
DR   DNASU; 1029508; -.
DR   EnsemblBacteria; AAN58317; AAN58317; SMU_576.
DR   GeneID; 66817953; -.
DR   KEGG; smu:SMU_576; -.
DR   PATRIC; fig|210007.7.peg.511; -.
DR   eggNOG; COG3279; Bacteria.
DR   HOGENOM; CLU_000445_14_1_9; -.
DR   OMA; DIHMPDF; -.
DR   PhylomeDB; Q8DVB7; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..244
FT                   /note="Sensory transduction protein LytR"
FT                   /id="PRO_0000081137"
FT   DOMAIN          2..118
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          140..244
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         55
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   244 AA;  27913 MW;  B7361ACFAB10DF4C CRC64;
     MNILILDDEM LARQELTFLI QQSKELDHPD IFEAEDISSA EKILFRQQID LIFLDISLSE
     ENGFTLANQL EQLAHPPLVV FATAYDHYAV KAFESNAADY ILKPFEQGRV DKALAKVKKI
     QHLSTIDETA TTEKKGMELL TLTLADRSIV LKMPDIVAAS IEDGELTVST KNTSYTIKKT
     LNWFKTRAKT NYFLQIHRNT VVNLEMIQEI QPWFNHTLLL VMVNGEKFPV GRSYMKELNA
     HLTL