ID   5MP2_XENLA              Reviewed;         419 AA.
AC   Q8AVM7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=eIF5-mimic protein 2 {ECO:0000250|UniProtKB:Q7L1Q6};
DE   AltName: Full=Basic leucine zipper and W2 domain-containing protein 1;
GN   Name=bzw1; Synonyms=5mp2 {ECO:0000250|UniProtKB:Q7L1Q6};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Translation initiation regulator which may repress repeat-
CC       associated non-AUG (RAN) initiated translation probably by acting as a
CC       competitive inhibitor of eukaryotic translation initiation factor 5
CC       (EIF5) function (By similarity). Enhances histone H4 gene transcription
CC       but does not seem to bind DNA directly (By similarity).
CC       {ECO:0000250|UniProtKB:Q7L1Q6}.
CC   -!- SIMILARITY: Belongs to the BZW family. {ECO:0000305}.
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DR   EMBL; BC041729; AAH41729.1; -; mRNA.
DR   RefSeq; NP_001080291.1; NM_001086822.1.
DR   AlphaFoldDB; Q8AVM7; -.
DR   SMR; Q8AVM7; -.
DR   DNASU; 379983; -.
DR   GeneID; 379983; -.
DR   KEGG; xla:379983; -.
DR   CTD; 379983; -.
DR   Xenbase; XB-GENE-5740857; bzw1.L.
DR   OMA; GNMEMEL; -.
DR   OrthoDB; 653740at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 379983; Expressed in lung and 19 other tissues.
DR   GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR   CDD; cd11560; W2_eIF5C_like; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR043510; W2_BZW1/2.
DR   InterPro; IPR003307; W2_domain.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51363; W2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..419
FT                   /note="eIF5-mimic protein 2"
FT                   /id="PRO_0000254616"
FT   DOMAIN          247..414
FT                   /note="W2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00695"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   419 AA;  48137 MW;  0816602286B13644 CRC64;
     MNNQKQQKPT LSGQRFKTRK RDEKERFDPT QFQDCIIQGL NETGNDLEAV AKFLDASGAK
     LDYRRYAETL FDILVAGGML APGGTLADEV IRTDVCVFSA QEDLETMQAF AQVFNKLIRR
     YKYLEKGFEE EVKKLLLFLK GFSESERNKL AMLTGILLAN GNLSASILNS LYNENLVKEG
     VSAAFAVKLF KSWINEKDIN AVAGSLRKVN MDNRLMELFP ANKQTVEHFT KYYTDAGLKE
     LAEYVRNQQT IGARKEIHKE LQEMISRGEA HKEISVYVKD EMKKNNISEQ TVIGILWSSI
     MSCVEWNKKE ELVTEQAIKH LKQYSPLLAA FTTQGQSELT LLLKIQEYCY DNIHFMKSFQ
     KIVVLFYKAE VLSEEPILKW YKDAHVAKGK SVFLEQMKKF VEWLKNAEEE SESETEEGD