ID   LYTS_STRA3              Reviewed;         581 AA.
AC   Q8E7H4;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Sensor protein LytS;
DE            EC=2.7.13.3;
GN   Name=lytS; OrderedLocusNames=gbs0180;
OS   Streptococcus agalactiae serotype III (strain NEM316).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=211110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEM316;
RX   PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA   Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA   Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT   "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT   neonatal disease.";
RL   Mol. Microbiol. 45:1499-1513(2002).
CC   -!- FUNCTION: Member of the two-component regulatory system LytR/LytS that
CC       probably regulates genes involved in cell wall metabolism.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
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DR   EMBL; AL766844; CAD45825.1; -; Genomic_DNA.
DR   RefSeq; WP_000930334.1; NC_004368.1.
DR   AlphaFoldDB; Q8E7H4; -.
DR   SMR; Q8E7H4; -.
DR   STRING; 211110.gbs0180; -.
DR   EnsemblBacteria; CAD45825; CAD45825; CAD45825.
DR   KEGG; san:gbs0180; -.
DR   eggNOG; COG3275; Bacteria.
DR   HOGENOM; CLU_020473_3_3_9; -.
DR   OMA; RVARNEM; -.
DR   Proteomes; UP000000823; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0071555; P:cell wall organization; IEA:InterPro.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR   InterPro; IPR011620; Sig_transdc_His_kinase_LytS_TM.
DR   Pfam; PF07694; 5TM-5TMR_LYT; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF06580; His_kinase; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Transferase; Transmembrane; Transmembrane helix;
KW   Two-component regulatory system.
FT   CHAIN           1..581
FT                   /note="Sensor protein LytS"
FT                   /id="PRO_0000074801"
FT   TRANSMEM        4..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          231..355
FT                   /note="GAF"
FT   DOMAIN          356..571
FT                   /note="Histidine kinase"
FT   MOD_RES         383
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   581 AA;  64549 MW;  D80F51DFF5ECAA12 CRC64;
     MLMVLLFQRL GIIMILAFLL VNNSYFRQLI EERSKRETVV LVIIFGLFVI ISNITGIEIK
     GDRSLVERPF LTTISHSDSL ANTRTLVITT ASLVGGPLVG SIVGFIGGVH RFFQGSFSGS
     FYIVSSVLVG IVSGKIGDKL KENHLYPSTS QVILISIIAE SIQMLFVGIF TGWELVKMIV
     IPMMILNSLG STLFLAILKT YLSNESQLRA VQTRDVLELT RQTLPYLRQG LTPQSARSVC
     EIIKRHTNFD AVGLTDRSNV LAHIGVGHDH HIAGQPVKTD LSKSVIFDGE PRIAQDKAAI
     SCPDHNCQLN SAIVVPLKIN DKTVGALKMY FAGDKTMSEV EENLVLGLAQ IFSGQLAMGI
     TEEQNKLASM AEIKALQAQI NPHFFFNAIN TISALIRIDS DKARYALMQL STFFRTSLQG
     GQDREVTLEQ EKSHVDAYMN VEKLRFPDKY QLSYDISAPE KMKLPPFGLQ VLVENAVRHA
     FKERKTDNHI LVQIKPDGHY YCVSVSDNGQ GISDTIIDKL GQETVAESKG TGTALVNLNN
     RLNLLYGSVS CLHFSSDKNG TKVWYRIPNR IREDEHENFN S