LYZL1_HUMAN
ID LYZL1_HUMAN Reviewed; 148 AA.
AC Q6UWQ5; Q5T921; Q8WW16;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Lysozyme-like protein 1;
DE EC=3.2.1.17;
DE Flags: Precursor;
GN Name=LYZL1; Synonyms=LYC2; ORFNames=UNQ648/PRO1278;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PRO-62.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT PRO-62.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC between N-acetyl-D-glucosamine residues in chitodextrins.;
CC EC=3.2.1.17;
CC -!- SUBUNIT: Monomer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UWQ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UWQ5-2; Sequence=VSP_019402;
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00680}.
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DR EMBL; AY358694; AAQ89057.1; -; mRNA.
DR EMBL; AL158167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021730; AAH21730.1; -; mRNA.
DR CCDS; CCDS31174.1; -. [Q6UWQ5-1]
DR RefSeq; NP_115906.3; NM_032517.4. [Q6UWQ5-1]
DR AlphaFoldDB; Q6UWQ5; -.
DR SMR; Q6UWQ5; -.
DR BioGRID; 124142; 146.
DR IntAct; Q6UWQ5; 38.
DR STRING; 9606.ENSP00000364650; -.
DR CAZy; GH22; Glycoside Hydrolase Family 22.
DR GlyGen; Q6UWQ5; 1 site.
DR iPTMnet; Q6UWQ5; -.
DR PhosphoSitePlus; Q6UWQ5; -.
DR BioMuta; LYZL1; -.
DR DMDM; 109892574; -.
DR MassIVE; Q6UWQ5; -.
DR PaxDb; Q6UWQ5; -.
DR PeptideAtlas; Q6UWQ5; -.
DR PRIDE; Q6UWQ5; -.
DR ProteomicsDB; 67512; -. [Q6UWQ5-1]
DR ProteomicsDB; 67513; -. [Q6UWQ5-2]
DR Antibodypedia; 12859; 152 antibodies from 26 providers.
DR DNASU; 84569; -.
DR Ensembl; ENST00000375500.8; ENSP00000364650.3; ENSG00000120563.10. [Q6UWQ5-2]
DR Ensembl; ENST00000649382.2; ENSP00000498092.1; ENSG00000120563.10. [Q6UWQ5-1]
DR GeneID; 84569; -.
DR KEGG; hsa:84569; -.
DR MANE-Select; ENST00000649382.2; ENSP00000498092.1; NM_032517.6; NP_115906.4.
DR UCSC; uc001iul.4; human. [Q6UWQ5-1]
DR CTD; 84569; -.
DR GeneCards; LYZL1; -.
DR HGNC; HGNC:30502; LYZL1.
DR HPA; ENSG00000120563; Tissue enriched (testis).
DR neXtProt; NX_Q6UWQ5; -.
DR OpenTargets; ENSG00000120563; -.
DR PharmGKB; PA134868520; -.
DR VEuPathDB; HostDB:ENSG00000120563; -.
DR eggNOG; ENOG502SCGK; Eukaryota.
DR GeneTree; ENSGT00940000159227; -.
DR HOGENOM; CLU_111620_0_0_1; -.
DR InParanoid; Q6UWQ5; -.
DR OMA; TWCRRAK; -.
DR PhylomeDB; Q6UWQ5; -.
DR TreeFam; TF324882; -.
DR PathwayCommons; Q6UWQ5; -.
DR SignaLink; Q6UWQ5; -.
DR BioGRID-ORCS; 84569; 12 hits in 997 CRISPR screens.
DR ChiTaRS; LYZL1; human.
DR GenomeRNAi; 84569; -.
DR Pharos; Q6UWQ5; Tbio.
DR PRO; PR:Q6UWQ5; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q6UWQ5; protein.
DR Bgee; ENSG00000120563; Expressed in left testis and 36 other tissues.
DR ExpressionAtlas; Q6UWQ5; baseline and differential.
DR Genevisible; Q6UWQ5; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0003796; F:lysozyme activity; IBA:GO_Central.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR019799; Glyco_hydro_22_CS.
DR InterPro; IPR000974; Glyco_hydro_22_lys.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR030057; LYZL1/LYZL2.
DR PANTHER; PTHR11407; PTHR11407; 1.
DR PANTHER; PTHR11407:SF62; PTHR11407:SF62; 1.
DR Pfam; PF00062; Lys; 1.
DR PRINTS; PR00137; LYSOZYME.
DR PRINTS; PR00135; LYZLACT.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF53955; SSF53955; 1.
DR PROSITE; PS00128; GLYCOSYL_HYDROL_F22_1; 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Glycosidase; Hydrolase;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..148
FT /note="Lysozyme-like protein 1"
FT /id="PRO_0000240635"
FT DOMAIN 20..148
FT /note="C-type lysozyme"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT ACT_SITE 54
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT ACT_SITE 71
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 25..145
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 49..133
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 83..98
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 94..112
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT VAR_SEQ 1
FT /note="M -> MQDAPLSCLSPTKWSSVSSADSTEKSASGAGTRNLPFQFCLRQALRM
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019402"
FT VARIANT 62
FT /note="Q -> P (in dbSNP:rs3818551)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_026817"
FT CONFLICT Q6UWQ5-2:13
FT /note="K -> R (in Ref. 3; AAH21730)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 148 AA; 16654 MW; AA90D3C84CB90BDA CRC64;
MKAAGILTLI GCLVTGAESK IYTRCKLAKI FSRAGLDNYW GFSLGNWICM AYYESGYNTT
AQTVLDDGSI DYGIFQINSF AWCRRGKLKE NNHCHVACSA LITDDLTDAI ICARKIVKET
QGMNYWQGWK KHCEGRDLSE WKKGCEVS
